Cannabis exposure and risk of testicular cancer: a systematic review and meta-analysis

BMC Cancer

Research Article

D. Sarfati¹  C. Shaw¹  V. Signal¹  J. Stanley¹  J. Gurney¹ 

[1] Department of Public Health, University of Otago, PO Box 7343, Wellington, New Zealand;

关键词: Testicular cancer;    Testicular germ cell tumour;    Cannabis;    Marijuana;    Marihuana;    Seminoma;    Non-seminoma;   

DOI  :  10.1186/s12885-015-1905-6

 received in 2015-07-30, accepted in 2015-11-03,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe aetiology of testicular cancer remains elusive. In this manuscript, we review the evidence regarding the association between cannabis use and testicular cancer development.MethodsIn this systematic review and meta-analysis, we reviewed literature published between 1st January 1980 and 13th May 2015 and found three case–control studies that investigated the association between cannabis use and development of testicular germ cell tumours (TGCTs).Results/ConclusionsUsing meta-analysis techniques, we observed that a) current, b) chronic, and c) frequent cannabis use is associated with the development of TGCT, when compared to never-use of the drug. The strongest association was found for non-seminoma development – for example, those using cannabis on at least a weekly basis had two and a half times greater odds of developing a non-seminoma TGCT compared those who never used cannabis (OR: 2.59, 95 % CI 1.60–4.19). We found inconclusive evidence regarding the relationship between cannabis use and the development of seminoma tumours. It must be noted that these observations were derived from three studies all conducted in the United States; and the majority of data collection occurred during the 1990’s.

【 授权许可】

CC BY   
© Gurney et al. 2015