Cardiovascular magnetic resonance tagging of the right ventricular free wall for the assessment of long axis myocardial function in congenital heart disease

Journal of Cardiovascular Magnetic Resonance

Research

Andrew W Dowsey¹  Guang-Zhong Yang¹  Wei Li²  Sylvia SM Chen²  Ricardo Wage²  Jennifer Keegan³  David N Firmin³  Philip J Kilner³  Tevfik Ismail³ 

[1] Imperial College, South Kensington Campus, SW7 2AZ, London, UK;Royal Brompton Hospital, Sydney Street, SW3 6NP, London, UK;Royal Brompton Hospital, Sydney Street, SW3 6NP, London, UK;Imperial College, South Kensington Campus, SW7 2AZ, London, UK;

关键词: Right Ventricle;    Ejection Fraction;    Cardiac MRI;    Tagging;    Congenital Heart Disease;    Reproducibility;   

DOI  :  10.1186/1532-429X-13-80

 received in 2011-05-02, accepted in 2011-12-14,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundRight ventricular ejection fraction (RV-EF) has traditionally been used to measure and compare RV function serially over time, but may be a relatively insensitive marker of change in RV myocardial contractile function. We developed a cardiovascular magnetic resonance (CMR) tagging-based technique with a view to rapid and reproducible measurement of RV long axis function and applied it in patients with congenital heart disease.MethodsWe studied 84 patients: 56 with repaired Tetralogy of Fallot (rTOF); 28 with atrial septal defect (ASD): 13 with and 15 without pulmonary hypertension (RV pressure > 40 mmHG by echocardiography). For comparison, 20 healthy controls were studied. CMR acquisitions included an anatomically defined four chamber cine followed by a cine gradient echo-planar sequence in the same plane with a labelling pre-pulse giving a tag line across the basal myocardium. RV tag displacement was measured with automated registration and tracking of the tag line together with standard measurement of RV-EF.ResultsMean RV displacement was higher in the control (26 ± 3 mm) than in rTOF (16 ± 4 mm) and ASD with pulmonary hypertension (18 ± 3 mm) groups, but lower than in the ASD group without (30 ± 4 mm), P < 0.001. The technique was reproducible with inter-study bias ± 95% limits of agreement of 0.7 ± 2.7 mm. While RV-EF was lower in rTOF than in controls (49 ± 9% versus 57 ± 6%, P < 0.001), it did not differ between either ASD group and controls.ConclusionsMeasurements of RV long axis displacement by CMR tagging showed more differences between the groups studied than did RV-EF, and was reproducible, quick and easy to apply. Further work is needed to assess its potential use for the detection of longitudinal changes in RV myocardial function.

【 授权许可】

Unknown   
© Chen et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.