Serotype- and strain- dependent contribution of the sensor kinase CovS of the CovRS two-component system to Streptococcus pyogenes pathogenesis

BMC Microbiology

Research Article

Regina Arlt¹  Tomas Fiedler¹  Catur Riani¹  Andreas Podbielski¹  Venelina Sugareva¹  Bernd Kreikemeyer¹ 

[1] Dept. of Med. Microbiology and Hospital Hygiene, University of Rostock, Medical Faculty, Inst. of Med. Microbiology, Virology and Hygiene, Schillingallee 70, 18055, Rostock, Germany;

关键词: Hyaluronic Acid;    Parental Wild Type Strain;    Serotype Strain;    Phagocytic Killing;    Keratinocyte Adherence;   

DOI  :  10.1186/1471-2180-10-34

 received in 2009-05-27, accepted in 2010-02-01,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe Streptococcus pyogenes (group A streptococci, GAS) two-component signal transduction system CovRS has been described to be important for pathogenesis of this exclusively human bacterial species. If this system acts uniquely in all serotypes is currently unclear. Presence of serotype- or strain-dependent regulatory circuits and polarity is an emerging scheme in Streptococcus pyogenes pathogenesis. Thus, the contribution of the sensor kinase (CovS) of the global regulatory two-component signal transduction system CovRS on pathogenesis of several M serotypes was investigated.ResultsCovS mutation uniformly repressed capsule expression and hampered keratinocyte adherence in all tested serotypes. However, a serotype- and even strain-dependent contribution on survival in whole human blood and biofilm formation was noted, respectively.ConclusionsThese data provide new information on the action of the CovS sensor kinase and revealed that its activity on capsule expression and keratinocyte adherence is uniform across serotypes, whereas the influence on biofilm formation and blood survival is serotype or even strain dependent. This adds the CovRS system to a growing list of serotype-specific acting regulatory loci in S. pyogenes.

【 授权许可】

Unknown   
© Sugareva et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.