Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management

Thrombosis Journal

Review

Bastian Hass¹  Martin Feuring²  Andreas Clemens³  Jayne Pooley⁴  Adrian E Harrington⁴ 

[1] Boehringer Ingelheim GmbH, Binger Strasse 173, 55216, Ingelheim am Rhein, Germany;Boehringer Ingelheim Pharma GmbH Co.KG, Binger Strasse 173, 55216, Ingelheim am Rhein, Germany;Boehringer Ingelheim Pharma GmbH Co.KG, Binger Strasse 173, 55216, Ingelheim am Rhein, Germany;Center of Thrombosis and Hemostasis,Johannes Gutenberg University, Medical Center, Mainz, Germany;United BioSource Corporation, River House, 33 Point Pleasant, SW18INN, London, UK;

关键词: Venous thromboembolism;    Anticoagulants;    Vitamin K antagonists;    Heparin;    Recurrence;    Bleeding;   

DOI  :  10.1186/1477-9560-10-24

 received in 2012-07-05, accepted in 2012-12-19,  发布年份 2012

来源: Springer

【 摘 要 】

Effective treatment of venous thromboembolism (VTE) strikes a balance between prevention of recurrence and bleeding complications. The current standard of care is heparin followed by a vitamin K antagonist such as warfarin. However, this option is not without its limitations, as the anticoagulant effect of warfarin is associated with high inter- and intra-patient variability and patients must be regularly monitored to ensure that anticoagulation is within the narrow target therapeutic range. Several novel oral anticoagulant agents are in the advanced stages of development for VTE treatment, some of which are given after an initial period of heparin treatment, in line with current practice, while others switch from high to low doses after the initial phase of treatment. In this review we assess the critical considerations for treating VTE in light of emerging clinical data for new oral agents and discuss the merits of novel treatment regimens for patients who have experienced an episode of deep vein thrombosis or pulmonary embolism.

【 授权许可】

CC BY   
© Hass et al.; licensee BioMed Central Ltd. 2012