Biocatalytic Buoyancy-Driven Nanobots for Autonomous Cell Recognition and Enrichment

Nano-Micro Letters

Article

Biao Kong¹  Joseph Wang²  Chenchen Zhuang³  John M. Whitelock⁴  Yihang Song⁵  Zhong Guo⁵  Joel Yong⁶  Kang Liang⁷  Ziyi Guo⁸  Yi Li⁹ 

[1] Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, 200438, Shanghai, People’s Republic of China;Department of Nanoengineering, University of California San Diego, 92093, La Jolla, CA, USA;General Intensive Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;Graduate School of Biomedical Engineering, The University of New South Wales, 2052, Sydney, NSW, Australia;Medical College, Northwest Minzu University, 730000, Lanzhou, People’s Republic of China;School of Chemical Engineering, Australian Centre for NanoMedicine, The University of New South Wales, 2052, Sydney, NSW, Australia;School of Chemical Engineering, Australian Centre for NanoMedicine, The University of New South Wales, 2052, Sydney, NSW, Australia;Graduate School of Biomedical Engineering, The University of New South Wales, 2052, Sydney, NSW, Australia;School of Chemical Engineering, Australian Centre for NanoMedicine, The University of New South Wales, 2052, Sydney, NSW, Australia;Medical College, Northwest Minzu University, 730000, Lanzhou, People’s Republic of China;School/Hospital of Stomatology, Lanzhou University, 730000, Lanzhou, People’s Republic of China;

关键词: Nanobots;    Surface functionalization;    Cell recognition;    Cell separation;    Metal–organic frameworks;   

DOI  :  10.1007/s40820-023-01207-1

 received in 2023-06-14, accepted in 2023-09-01,  发布年份 2023

来源: Springer

【 摘 要 】

tsA self-propelled, biocatalytic buoyancy-driven metal–organic framework (MOF) nanobot is developed.The anti-carcinoembryonic antigen antibody functionalized MOF nanobot demonstrates directional vertical motion to “find-and-fetch” cancer cells from mixed cell population.The captured cells can be recovered with full metabolic potential.

【 授权许可】

CC BY   
© Shanghai Jiao Tong University 2023

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