The correlation between serum lipid profile with carotid intima-media thickness and plaque

BMC Cardiovascular Disorders

Research Article

Zhiqiang Sun¹  Yunpeng Li¹  Junping Ai¹  Yaping Tian¹  Qiyu Sun¹  Caie Yang² 

[1] Department of Clinical Biochemistry, Chinese PLA General Hospital, No. 28 Fuxing Road, 100853, Beijing, China;Department of Clinical Biochemistry, Chinese PLA General Hospital, No. 28 Fuxing Road, 100853, Beijing, China;Department of Clinical Laboratory, Chinese PLA 309 Hospital, No. 17 Heishanhu Road, 100091, Beijing, China;

关键词: Subclinical atherosclerosis;    Lipid ratio;    Intima-media thickness;    Plaque;   

DOI  :  10.1186/1471-2261-14-181

 received in 2014-09-06, accepted in 2014-12-03,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIt is indicated that non-HDL cholesterol and lipid ratios, including total/HDL cholesterol and LDL/HDL cholesterol ratios, are risk indicators with greater predictive value for coronary atherosclerotic progression or regression compared with conventional lipid profile. However, there have been few reports about the correlation between serum lipid profile with carotid intima-media thickness (IMT) and plaque in Chinese general people.MethodsWe examined 402 subjects without apparent diseases in a cross-sectional study (mean age 50.16 years; 36.07% female). Demographics, anthropometrics, and laboratory data were collected. The presence of carotid plaque and intima-media thickness were evaluated by ultrasonography.ResultsUnivariate correlations showed carotid IMT was correlated with LDL-C (r = 0.137, p = 0.009), non-LDL-C levels (r = 0.140, p = 0.008) and LDL-C/HDL-C ratio (r = 0.169, p = 0.001). After adjustment for potential covariates, LDL-C/HDL-C ratio (β = 0.132, p < 0.001) were independent variables that interacted on carotid IMT. Other risk factors including age and systolic blood pressure were independently associated with carotid IMT. LDL-C levels, non-HDL-C levels, TC/HDL-C and LDL-C/HDL-C ratios were significantly higher, but HDL-C levels were significantly lower in subjects with carotid plaque than those without it. The subsequent multiple logistic regression analysis showed that LDL-C (OR; 1.325, 95% CI; 1.046-1.821, p = 0.033) and HDL-C levels (OR; 0.093, 95% CI; 0.038-0.227, p < 0.001) were significantly associated with the presence of carotid plaque after adjustment of age. Furthermore, LDL-C combined with HDL-C levels showed the highest area under the curve (0.788, 95% CI; 0.740–0.837, p < 0.001).ConclusionsSerum LDL-C/HDL-C ratio represents as an independent index associated with increased carotid IMT and LDL-C combined with HDL-C levels may be useful markers for predicting the presence of carotid plaque in the Chinese general population.

【 授权许可】

Unknown   
© Yang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.