Influence of diet on the gut microbiome and implications for human health

Journal of Translational Medicine

Review

Tina Bhutani¹  Kristina M. Lee¹  Hsin-Wen Chang¹  Di Yan¹  Kirsten Wong¹  Derya Ucmak¹  Mio Nakamura¹  Wilson Liao¹  Michael Abrouk²  Rasnik K. Singh³  Tian Hao Zhu⁴  Benjamin Farahnik⁵ 

[1] Department of Dermatology, University of California, San Francisco, Box 0808, 2340 Sutter St. Room N431, 94115, San Francisco, CA, USA;University of California, Irvine, School of Medicine, 92697, Irvine, CA, USA;University of California, Los Angeles, David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA;University of Southern California Keck School of Medicine, 90033, Los Angeles, CA, USA;University of Vermont College of Medicine, 05405, Burlington, VT, USA;

关键词: Diet;    Health;    Metabolism;    Microbiome;    Microbiota;    Nutrition;   

DOI  :  10.1186/s12967-017-1175-y

 received in 2016-09-30, accepted in 2017-03-21,  发布年份 2017

来源: Springer

【 摘 要 】

Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, and cancer. At the same time, it is now understood that diet plays a significant role in shaping the microbiome, with experiments showing that dietary alterations can induce large, temporary microbial shifts within 24 h. Given this association, there may be significant therapeutic utility in altering microbial composition through diet. This review systematically evaluates current data regarding the effects of several common dietary components on intestinal microbiota. We show that consumption of particular types of food produces predictable shifts in existing host bacterial genera. Furthermore, the identity of these bacteria affects host immune and metabolic parameters, with broad implications for human health. Familiarity with these associations will be of tremendous use to the practitioner as well as the patient.

【 授权许可】

CC BY   
© The Author(s) 2017