Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study

Lipids in Health and Disease

Research

Richard J Bloomer¹  Robert E Canale¹  Sujata Suvarnapathki²  Sid Shastri³ 

[1] Cardiorespiratory/Metabolic Laboratory, Department of Health and Sport Sciences, University of Memphis, Memphis, TN, USA;Sankhya Analytical Research, Mumbai, India;Shastri Tech, Los Angeles, CA, USA;

关键词: Free Fatty Acid;    Capsaicin;    Glycerol Concentration;    Respiratory Exchange Ratio;    Dihydrocapsaicin;   

DOI  :  10.1186/1476-511X-9-72

 received in 2010-06-29, accepted in 2010-07-15,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIn the present investigation we compared blood epinephrine (EPI), norepinephrine (NE), free fatty acids (FFA) and glycerol concentrations in response to a capsaicinoid supplement or placebo in healthy adults before and after acute exercise.MethodsTwenty subjects ingested a placebo or supplement (Capsimax™, OmniActive Health Technologies; 2 mg capsaicinoids in a microencapsulated matrix) with one week separating conditions. Fasting blood samples were collected during each visit; 30 minutes following a rest period and before placebo or supplement intake (Pre); 2 hours post intake (2 hr); one minute following the cessation of 30 minutes of exercise performed at 65% of maximal heart rate reserve (2.5 hr); 90 minutes following the cessation of exercise (4 hr). Heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure were recorded at all times.ResultsA time effect was noted for HR, SBP, and DBP (p < 0.05), with HR and SBP higher at 2.5 hr compared to Pre (due to exercise) and DBP lower at 2.5 hr compared to Pre. No interaction or condition effects were noted for EPI, NE, FFA, or glycerol (p > 0.05). However, a time effect was noted for all variables (p < 0.0001), with values higher than Pre at 2.5 hr for EPI and glycerol, at 2 hr and 2.5 hours for FFA, and at 2 hr, 2.5 hr, and 4 hr for NE (p < 0.05). In terms of percent change from Pre, glycerol was higher with Capsimax™ than for placebo at 4 hr (p = 0.011) and FFA was higher with Capsimax™ than for placebo at 2 hr (p = 0.025) and at 2.5 hr (p = 0.015).ConclusionIngestion of low dose (2 mg) Capsimax™ was associated with an increase in blood FFA and glycerol at selected times post ingestion, as compared to placebo. However, Capsimax™ had no differing effect on EPI or NE compared to placebo. Lastly, no difference was noted in HR, SBP, or DBP between placebo and Capsimax™.

【 授权许可】

CC BY   
© Bloomer et al; licensee BioMed Central Ltd. 2010