The role of toll-like receptors in acute and chronic lung inflammation

Journal of Inflammation

Review

Erin I Lafferty¹  Salman T Qureshi²  Markus Schnare³ 

[1] Division of Experimental Medicine, McGill University, H3A 1A3, Montréal, Québec, Canada;Division of Experimental Medicine, McGill University, H3A 1A3, Montréal, Québec, Canada;Department of Medicine, McGill University, H3A 1A1, Montréal, Québec, Canada;Institute of Immunology, Philipps-University of Marburg, Germany;

关键词: Chronic Obstructive Pulmonary Disease;    Influenza;    Cystic Fibrosis;    Respiratory Syncytial Virus;    Acute Lung Injury;   

DOI  :  10.1186/1476-9255-7-57

 received in 2010-07-07, accepted in 2010-11-25,  发布年份 2010

来源: Springer

【 摘 要 】

By virtue of its direct contact with the environment, the lung is constantly challenged by infectious and non-infectious stimuli that necessitate a robust yet highly controlled host response coordinated by the innate and adaptive arms of the immune system. Mammalian Toll-like receptors (TLRs) function as crucial sentinels of microbial and non-infectious antigens throughout the respiratory tract and mediate host innate immunity. Selective induction of inflammatory responses to harmful environmental exposures and tolerance to innocuous antigens are required to maintain tissue homeostasis and integrity. Conversely, dysregulated innate immune responses manifest as sustained and self-perpetuating tissue damage rather than controlled tissue repair. In this article we review aspects of Toll-like receptor function that are relevant to the development of acute lung injury and chronic obstructive lung diseases as well as resistance to frequently associated microbial infections.

【 授权许可】

Unknown   
© Lafferty et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.