Enhanced chlorhexidine skin penetration with 1,8-cineole

BMC Infectious Diseases

Research Article

R. Waters¹  A. L. Casey²  T. J. Karpanen²  T. S. J. Elliott³  B. R. Conway⁴  T. Worthington⁵  P. Nightingale⁶ 

[1] Department of Burns and Plastics, University Hospitals Birmingham NHS Foundation Trust, B15 2WB, Birmingham, UK;Department of Clinical Microbiology, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, B15 2WB, Birmingham, UK;Department of Clinical Microbiology, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, B15 2WB, Birmingham, UK;Clinical Governance, The Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, B15 2TH, Birmingham, UK;Department of Pharmacy, University of Huddersfield, Queensgate, HD1 3DH, Huddersfield, UK;School of Life and Health Sciences, Aston University, B4 7ET, Birmingham, UK;Wolfson Computer Laboratory, University Hospitals Birmingham NHS Foundation Trust, B15 2TH, Birmingham, UK;

关键词: Skin antisepsis;    Antiseptic penetration;    Terpene;   

DOI  :  10.1186/s12879-017-2451-4

 received in 2016-05-27, accepted in 2017-05-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundChlorhexidine (CHG) penetrates poorly into skin. The purpose of this study was to compare the depth of CHG skin permeation from solutions containing either 2% (w/v) CHG and 70% (v/v) isopropyl alcohol (IPA) or 2% (w/v) CHG, 70% (v/v) IPA and 2% (v/v) 1,8-cineole.MethodsAn ex-vivo study using Franz diffusion cells was carried out. Full thickness human skin was mounted onto the cells and a CHG solution, with or without 2% (v/v) 1,8-cineole was applied to the skin surface. After twenty-four hours the skin was sectioned horizontally in 100 μm slices to a depth of 2000 μm and the concentration of CHG in each section quantified using high performance liquid chromatography (HPLC). The data were analysed with repeated measures analysis of variance.ResultsThe concentration of CHG in the skin on average was significantly higher (33.3% [95%, CI 1.5% - 74.9%]) when a CHG solution which contained 1,8-cineole was applied to the skin compared to a CHG solution which did not contain this terpene (P = 0.042).ConclusionsEnhanced delivery of CHG can be achieved in the presence of 1,8-cineole, which is the major component of eucalyptus oil. This may reduce the numbers of microorganisms located in the deeper layers of the skin which potentially could decrease the risk of surgical site infection.

【 授权许可】

CC BY   
© The Author(s). 2017