Clinical predictors of incident gallstone disease in a Chinese population in Taipei, Taiwan

BMC Gastroenterology

Research Article

Chung-Te Hsu¹  Jorn-Hon Liu²  Tao-Hsin Tung³  Jau-Yuan Chen⁴ 

[1] Cheng Hsin General Hospital, Taipei, Taiwan;Cheng Hsin General Hospital; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan;Cheng Hsin General Hospital; Faculty of Public Health, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan;Department of Family Medicine, Linkou Chang-Gung Memorial Hospital and Chang-Gung University, Taoyuan, Taiwan;

关键词: Follow-up study;    Gallstone disease (GSD);    Incidence density;    Predictive factors;    Screening;   

DOI  :  10.1186/1471-230X-14-83

 received in 2013-03-09, accepted in 2014-04-23,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundGallstone disease (GSD) is a common gastrointestinal disorder throughout the world. The authors explored the incidence of GSD in Taiwan and its condition-associated predictive factors.MethodsThe initial study cohort comprised 2386 healthy adult participants, who were voluntarily admitted to a teaching hospital for a physical check-up in 2002 in Taipei, Taiwan. After excluding 126 patients who exhibited prevalent GSD, 2260 non-GSD participants received annual follow-up screenings for GSD until 31 December, 2007. Of those, 1296 (57.3%) patients were re-examined to collect blood samples and conduct ultrasound sonography.ResultsAmong the 1296 participants who exhibited no GSD at the first screening, 23 patients developed GSD during 3640 person-years of follow-up. The incidence was 0.632% per year (95% CI: 0.292%–2.009%). After conducting a Cox regression, increased age (50–59 years versus < 40 years, RR = 2.16 [95% CI: 1.09–5.97], 60+ years versus < 40 years, RR = 3.81 [95% CI: 2.77–8.63]), high body mass index (≥27 kg/m2 versus < 24 kg/m2, RR = 1.64 [95% CI: 1.07–2.98]), high fasting plasma glucose levels (≥126 mg/dL versus < 110 mg/dL, RR = 1.68, 95% CI: 1.10–3.87), and nonalcoholic fatty liver disease (yes versus no, RR = 1.44, 95% CI: 1.21–1.90) appeared to be significantly related to developing GSD.ConclusionIncreased age is a well-established risk factor for developing GSD. The current findings indicated that high body mass index, elevated fasting plasma glucose levels, and nonalcoholic fatty liver disease were also associated with GSD.

【 授权许可】

Unknown   
© Chen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.