Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder

BMC Neuroscience

Research Article

Yasong Du¹  Jianrong Xu²  Xin Ge²  Mengqiu Cao²  Yan Zhou²  Xu Han²  Yawen Sun²  Yao Wang²  Weina Ding² 

[1] Department of Child & Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University, 200030, Shanghai, People’s Republic of China;Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, People’s Republic of China;

关键词: Functional magnetic resonance imaging;    Internet gaming disorder;    Nicotine dependence;    Resting-state functional connectivity;    Dorsolateral prefrontal cortex;   

DOI  :  10.1186/s12868-017-0375-y

 received in 2017-03-15, accepted in 2017-07-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIt has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This study is to investigate the alterations in the resting-state functional connectivity (rsFC) of the dorsolateral prefrontal cortex (DLPFC) observed in SND and IGD. In this study, 27 IGD, 29 SND, and 33 healthy controls (HC) underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. DLPFC connectivity was determined in all participates by investigating the synchronized low-frequency fMRI signal fluctuations using a temporal seed-based correlation method.ResultsCompared with the HC group, the IGD and SND groups showed decreased rsFC with DLPFC in the right insula and left inferior frontal gyrus with DLPFC. Compared with SND group, the IGD subjects exhibited increased rsFC in the left inferior temporal gyrus and right inferior orbital frontal gyrus and decreased rsFC in the right middle occipital gyrus, supramarginal gyrus, and cuneus with DLPFC.ConclusionOur results confirmed that SND and IGD share similar neural mechanisms related to craving and impulsive inhibitions. The significant difference in rsFC with DLPFC between the IGD and SND subjects may be attributed to the visual and auditory stimulation generated by long-term internet gaming.

【 授权许可】

CC BY   
© The Author(s) 2017