Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

BMC Cancer

Research Article

Toshiki Takei¹  Wataru Ichimura¹  Kenji Hirata²  Nagara Tamaki²  Masao Harada³  Keishi Kondo⁴  Takashi Hayashi⁵  Katsumi Shima⁵  Mitsunori Sekizawa⁵  Tomoka Kitao⁶ 

[1] Department of Diagnostic Radiology, Hokkaido Cancer Center, Sapporo, Japan;Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-Ku, 060-8638, Sapporo, Hokkaido, Japan;Department of Respiratory Medicine, Hokkaido Cancer Center, Sapporo, Japan;Department of Thoracic Surgery, Hokkaido Cancer Center, Sapporo, Japan;Radiology Department, National Hospital Organization, Hokkaido Cancer Center, 2-3-54, Kikusui-4, Shiroishi-Ku, 003-0804, Sapporo, Japan;Radiology Department, National Hospital Organization, Hokkaido Cancer Center, 2-3-54, Kikusui-4, Shiroishi-Ku, 003-0804, Sapporo, Japan;Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-Ku, 060-8638, Sapporo, Hokkaido, Japan;

关键词: Lung cancer;    Reproducibility;    Metabolic tumor volume;    Total lesion glycolysis;    FDG-PET;   

DOI  :  10.1186/s12885-016-2624-3

 received in 2016-02-09, accepted in 2016-07-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundVolume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response in nonsmall cell lung cancer (NSCLC). We aimed to examine intra- and inter-operator reproducibility to measure the MTV and TLG, and to estimate their dependency on the uptake time.MethodsFifty NSCLC patients underwent preoperative FDG-PET. After an injection of FDG, the whole body was scanned twice: at the early phase (61.4 ± 2.8 min) and delayed phase (117.7 ± 1.6 min). Two operators independently defined the tumor boundary using three different delineation methods: (1) the absolute SUV threshold method (MTVp and TLGp; p = 2.0, 2.5, 3.0, 3.5), (2) the fixed% SUVmax threshold method (MTVq% and TLGq%; q = 35, 40, 45), and (3) the adaptive region-growing method (MTVARG and TLGARG). Parameters were compared between operators and between phases.ResultsBoth the intra- and inter-operator reproducibility were high for all parameters using any method (intra-class correlation > 0.99 each). MTV3.0 and MTV3.5 resulted in a significant increase from the early to delayed phase (P < 0.05 for both), whereas MTV2.0 and MTV2.5 neither increased nor decreased (P = n.s.). All of the MTVq% values significantly decreased over time (P < 0.01), whereas MTVARG and TLG with any delineation method increased significantly (P < 0.05).ConclusionsHigh reproducibility of MTV and TLG was obtained by all of the methods used. MTV2.0 and MTV2.5 were the least sensitive to uptake time, and may be good alternatives when we compare images acquired with different uptake times, although applying constant uptake time is important for volume measurement.

【 授权许可】

CC BY   
© The Author(s). 2016