Prevalence of lower extremity Peripheral artery disease among adult diabetes patients in Southwestern Uganda

BMC Cardiovascular Disorders

Research Article

Stephen Bambeiha Asiimwe¹  Laurence Anthony Wilson²  Rogers Owori²  Samson Okello²  Joselyn Rwebembera²  Alexander Millard³  Christopher Charles Moore³  Brian Herb Annex⁴  Mark Jacob Siedner⁵ 

[1] Department of Medicine, Mbarara Regional Referral Hospital, Mbarara, Uganda;Department of Medicine, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda;Department of Medicine, University of Virginia, Charlottesville, Virginia, USA;Department of Medicine, University of Virginia, Charlottesville, Virginia, USA;The Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA;Harvard Medical School, Boston, Massachusetts, USA;

关键词: Glibenclamide;    Peripheral Arterial Disease;    Ankle Brachial Index;    Peripheral Arterial Disease Patient;    Claudication Symptom;   

DOI  :  10.1186/1471-2261-14-75

 received in 2014-03-05, accepted in 2014-06-05,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPeripheral artery disease (PAD) is a major complication of atherosclerosis. PAD can be diagnosed with low-cost diagnostic techniques and is associated with significant morbidity and mortality. While the major epidemiologic risk factors for PAD have been established in the western world, data from resource-poor countries are limited. We performed a cross-sectional study to determine the prevalence and correlates of PAD among patients with diabetes at Mbarara Referral Hospital in southwestern Uganda.MethodsWe consecutively enrolled diabetes patients aged 50 years or greater presenting to the outpatient clinic. We collected blood for fasting lipid profile, HIV serology, and glycosylated hemoglobin, measured blood pressure and ankle brachial index, and administered the Edinburgh Claudication Questionnaire (ECQ). We also surveyed patients for other PAD risk factors. We used logistic regression to determine correlates of PAD.ResultsWe enrolled 229 diabetes patients. The median age of 60 years (IQR 55–66), and 146 (63.7%) were female. Fifty five patients (24%) had PAD (ABI of ≤ 0.9). Of these, 48 /55 (87.27%) had mild PAD (ABI 0.71-0.9) while 7/55 (12.73%) had moderate to severe PAD (ABI < 0.7). Amongst those with PAD, 24/55 (43.64%) reported claudication by the ECQ. Correlates of PAD included female sex (AOR 2.25, 95% CI 1.06 - 4.77, p = 0.034), current high blood pressure (AOR 2.59, 95% CI 1.25-5.33, p = 0.01), and being on a sulfonylurea–glibenclamide (AOR 3.47, 95% CI 1.55 - 7.76, p = 0.002).ConclusionPAD was common in diabetic patients in southwestern Uganda. Given its low cost and ease of measurement, ABI deserves further assessment as a screening tool for both PAD and long term cardiovascular risk amongst diabetics in this region.

【 授权许可】

CC BY   
© Okello et al.; licensee BioMed Central Ltd. 2014