Journal of Cardiovascular Magnetic Resonance | |
Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy | |
Research | |
Sébastien Roujol1  Reza Nezafat2  Shadi Akhtari2  Jihye Jang2  Sophie Berg2  Francesca N. Delling2  Beth Goddu2  Shiro Nakamori2  Kraig V. Kissinger2  Tamer Basha3  Shingo Kato4  Warren J. Manning5  | |
[1] Biomedical Engineering Department, King’s College London, London, UK;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Biomedical Engineering Department, Cairo University, Giza, Egypt;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Department of Cardiology, Yokohama City University Hospital, Yokohama, Japan;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; | |
关键词: Cardiovascular Magnetic Resonance; Mitral Regurgitation; Late Gadolinium Enhancement; Papillary Muscle; Multivariate Linear Regression Analysis; | |
DOI : 10.1186/s12968-016-0301-y | |
received in 2016-07-21, accepted in 2016-10-29, 发布年份 2016 | |
来源: Springer | |
【 摘 要 】
BackgroundFunctional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis. We sought to evaluate the potential relationship between papillary muscle T1 time and mitral regurgitation in DCM patients.MethodsForty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied. Native T1 mapping was performed using a slice interleaved T1 mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation.ResultsPapillary muscle T1 time was significantly elevated in DCM patients with mitral regurgitation (n = 22) in comparison to those without mitral regurgitation (n = 18) (anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05), but LV T1 time was similar (1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93). Multivariate linear regression analysis showed that papillary muscle native T1 time (β = 0.10, 95 % CI: 0.05–0.17, p < 0.05) is significantly correlated with mitral regurgitant fraction. Elevated papillary muscle T1 time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values <0.05).ConclusionsIn DCM, papillary muscle native T1 time is significantly elevated and related to mitral regurgitant fraction.
【 授权许可】
CC BY
© The Author(s). 2016
【 预 览 】
Files | Size | Format | View |
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RO202311102177955ZK.pdf | 2285KB | download |
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