Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy

Journal of Cardiovascular Magnetic Resonance

Research

Sébastien Roujol¹  Reza Nezafat²  Shadi Akhtari²  Jihye Jang²  Sophie Berg²  Francesca N. Delling²  Beth Goddu²  Shiro Nakamori²  Kraig V. Kissinger²  Tamer Basha³  Shingo Kato⁴  Warren J. Manning⁵ 

[1] Biomedical Engineering Department, King’s College London, London, UK;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Biomedical Engineering Department, Cairo University, Giza, Egypt;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Department of Cardiology, Yokohama City University Hospital, Yokohama, Japan;Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, 02215, Boston, MA, USA;Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA;

关键词: Cardiovascular Magnetic Resonance;    Mitral Regurgitation;    Late Gadolinium Enhancement;    Papillary Muscle;    Multivariate Linear Regression Analysis;   

DOI  :  10.1186/s12968-016-0301-y

 received in 2016-07-21, accepted in 2016-10-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundFunctional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis. We sought to evaluate the potential relationship between papillary muscle T1 time and mitral regurgitation in DCM patients.MethodsForty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied. Native T1 mapping was performed using a slice interleaved T1 mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation.ResultsPapillary muscle T1 time was significantly elevated in DCM patients with mitral regurgitation (n = 22) in comparison to those without mitral regurgitation (n = 18) (anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05), but LV T1 time was similar (1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93). Multivariate linear regression analysis showed that papillary muscle native T1 time (β = 0.10, 95 % CI: 0.05–0.17, p < 0.05) is significantly correlated with mitral regurgitant fraction. Elevated papillary muscle T1 time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values <0.05).ConclusionsIn DCM, papillary muscle native T1 time is significantly elevated and related to mitral regurgitant fraction.

【 授权许可】

CC BY   
© The Author(s). 2016