Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis

Lipids in Health and Disease

Research

Cun S Fang¹  Jing Wu¹  Wei Wang¹  Chun Wang¹  Ying C Wang¹  Ming Y Zhang¹  Tao H Zhang¹ 

[1]Nine department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, 210029, Nanjing, P.R. China

关键词: pulmonary alveolar proteinosis;    high-density lipoprotein cholesterol lipid;    low-density lipoprotein cholesterol;    whole lung lavage;   

DOI  :  10.1186/1476-511X-11-12

 received in 2011-11-27, accepted in 2012-01-17,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIt is well known that pulmonary alveolar proteinosis(PAP) is characterised by accumulation of surfactant lipids and proteins within airspaces. However, few previous data describe the serum lipid levels associated with PAP.Materials and methodsWe retrospectively reviewed 25 patients with idiopathic PAP(iPAP). The serum lipid levels of patients with idiopathic PAP were compared with those of the healthy volunteers. In patients and healthy subjects, the LDL-C/HDL-C ratios were 2.94 ± 1.21 and 1.60 ± 0.70, respectively (p < 0.001), HDL-C were 1.11 ± 0.27 and 1.71 ± 0.71 respectively (p < 0.001). The values of LDL-C correlated significantly with those of PaO2 and PA-aO2 (r = -0.685, p = 0.003, and r = 0.688, p = 0.003, respectively). The values of LDL-C/HDL-C ratios also correlated with PaO2 levels and PA-aO2 levels (r = -0.698, p = 0.003, and r = 0.653, p = 0.006, respectively). 11 and 13 patients experienced respectively a decline in TC and LDL-C levels following whole lung lavage(WLL), the median decline was 0.71 mmol/L(p < 0.009) and 0.47 mmol/L(p < 0.003), respectively.Conclusionsthe serum lipid levels, especially the levels of LDL-C and LDL-C/HDL-C, may reflect the severity of the disease in PAP patients, and predict the therapeutic effect of WLL.

【 授权许可】

Unknown   
© Fang et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.