Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast

Cardiovascular Diabetology

Original Investigation

Oonagh Markey¹  Amir Shafat²  Conor M McClean³  Paul Medlow³  Gareth W Davison³  Ellie Duly⁴  Tom R Trinick⁴ 

[1] Department of Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland;Department of Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland;Department of Physiology, National University of Ireland, Galway, Galway, Ireland;Sport and Exercise Science Research Institute, University of Ulster, BT37 0QB, Belfast, Northern Ireland, UK;Ulster Hospital, Dundonald, BT16 1RH, Belfast, Northern Ireland, UK;

关键词: gastrointestinal;    antioxidant capacity;    obesity;    type 2 diabetes;    polyphenols;    fatty acids;    omega-3 fatty acids;   

DOI  :  10.1186/1475-2840-10-78

 received in 2011-08-23, accepted in 2011-09-07,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCinnamon has been shown to delay gastric emptying of a high-carbohydrate meal and reduce postprandial glycemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes and cardiovascular disease. We aimed to determine the effect of 3 g cinnamon (Cinnamomum zeylanicum) on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat meal.MethodsA single-blind randomized crossover study assessed nine healthy, young subjects. GE rate of a high-fat meal supplemented with 3 g cinnamon or placebo was determined using the 13C octanoic acid breath test. Breath, blood samples and subjective appetite ratings were collected in the fasted and during the 360 min postprandial period, followed by an ad libitum buffet meal. Gastric emptying and 1-day fatty acid intake relationships were also examined.ResultsCinnamon did not change gastric emptying parameters, postprandial triacylglycerol or glucose concentrations, oxidative stress, arterial function or appetite (p < 0.05). Strong relationships were evident (p < 0.05) between GE Thalf and 1-day palmitoleic acid (r = -0.78), eiconsenoic acid (r = -0.84) and total omega-3 intake (r = -0.72). The ingestion of 3 g cinnamon had no effect on GE, arterial stiffness and oxidative stress following a HF meal.Conclusions3 g cinnamon did not alter the postprandial response to a high-fat test meal. We find no evidence to support the use of 3 g cinnamon supplementation for the prevention or treatment of metabolic disease. Dietary fatty acid intake requires consideration in future gastrointestinal studies.Trial registrationTrial registration number: at http://www.clinicaltrial.gov: NCT01350284

【 授权许可】

Unknown   
© Markey et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.