Androgen receptor status predicts response to chemotherapy, not risk of breast cancer in Indian women

World Journal of Surgical Oncology

Research

Pranjal Kulshreshtha¹  LC Singh²  Anurupa Chakraborty²  Ashwani K Mishra²  Sunita Saxena²  Dinesh Bhatnagar² 

[1] Department of Surgery, Indian Council Of Medical Research, New Delhi, India;Vardhman Mahavir Medical College, Safdarjung Hospital, 110023, New Delhi, India;Vardhman Mahavir Medical College, Safdarjung Hospital, 110023, New Delhi, India;Institute Of Pathology, Indian Council Of Medical Research, New Delhi, India;

关键词: Breast Cancer;    Androgen Receptor;    Breast Cancer Risk;    Locally Advanced Breast Cancer;    Short Allele;   

DOI  :  10.1186/1477-7819-8-64

 received in 2009-12-21, accepted in 2010-08-04,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundConsiderably little is known about the biological role and clinical significance of androgen receptor expression in breast cancer. The objectives of this study were to characterize AR-CAG repeat genotypes in a cohort of women with breast cancer and to determine the influence of AR on response to neoadjuvant chemotherapy and clinical outcome.Materials and methodsGenotyping of the AR CAG repeat region was done on 70 patients and 80 healthy aged- matched female controls. To assess response to NACT, tissue samples from 30 LABC cases were evaluated quantitatively by real time for AR mRNA expression. The clinical response was correlated with both the pre and post chemotherapy AR expression. The CAG alleles did not show differences between cases and controls when the mean of short, long and average length of both CAG alleles was considered. However, analysis when done defining short allele as CAGn < 20 (AR1) and the long as CAGn ≥ 20 (AR2), risk was found associated with AR2 allele with marginal significance (P = 0.09). Stratification by age of onset, FH, stage, grade ER and AR status failed to reveal any association with breast cancer risk. Genotype carriers with ≥20 CAGn showed decrease of AR mRNA expression although significance could not be established (P = 0.47). Tumours in responders had the higher AR mRNA expression levels in pre neo-adjuvant chemotherapy condition (p < 0.02) which got reduced after neoadjuvant chemotherapy and the difference was found to be significant (P = 0.014).ConclusionsAlthough, expansion of the CAGn in the AR gene doesn't show any major effect on breast cancer risk, patients with positive AR expression, pre neoadjuvant chemotherapy, were found to be good responders and a decrease in mRNA level of AR gene related to the chemotherapy-induced apoptosis could serve as an important independent predictor of response to NACT.

【 授权许可】

CC BY   
© Chintamani et al; licensee BioMed Central Ltd. 2010