Hypovitaminosis D is associated with negative outcome in dogs with protein losing enteropathy: a retrospective study of 43 cases

BMC Veterinary Research

Research Article

J. Rizzo¹  K. Allenspach²  Y. M. Chang³  A. E. Jergens⁴ 

[1] Department of Clinical Sciences and Services, University of London, North Mymms, Hertfordshire, UK;Department of Clinical Sciences and Services, University of London, North Mymms, Hertfordshire, UK;Department of Clinical Sciences, Iowa State University College of Veterinary Medicine, 50011, Ames, IA, USA;Department of Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA;Research Support Office, Royal Veterinary College, University of London, North Mymms, Hertfordshire, UK;

关键词: Protein losing enteropathy (PLE);    Dog;    Risk factors;    Outcome;    Vitamin D3;    Ionized calcium;   

DOI  :  10.1186/s12917-017-1022-7

 received in 2016-07-13, accepted in 2017-04-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundHypovitaminosis D has previously been shown to be prevalent amongst dogs with protein losing enteropathy (PLE).The hypothesis of this study was that Low 25-hydroxyvitamin D (25(OH) D) serum concentrations could be a risk factor for negative outcome in dogs with PLE.Forty-three dogs diagnosed with PLE (2005–2014) and which serum Vitamin D serum concentrations were collected and archived at −80 Degrees C were analyzed.Post-diagnostic communication with referring veterinarians was made to determine outcome of PLE dogss: Dogs which died due to PLE within 4 months after diagnosis (negative outcome group, n = 22) and dogs alive or which died due to another disease at the end point of the study (1 year after diagnosis, good outcome group, n = 21). Serum samples taken at the time of diagnosis were analysed for ionized calcium (iCa) concentrations and serum 25(OH) D concentration.ResultsClinical (CCECAI) scores, age at PLE diagnosis, and iCa concentrations were not significantly different between dog groups. A significantly greater (p < 0.001) number of PLE dogs treated with hydrolyzed or elimination diet alone showed good outcome as compared to the PLE negative outcome group. Median serum 25(OH) D concentration was significantly (p = 0.017) lower in dogs with negative outcome versus PLE dogs with good outcome. Using logistic regression analysis, 25(OH) D serum concentration was shown to be a statistically significant factor for outcome determination. Cox regression analysis yielded a hazard ratio of 0.974 (95% CI 0.949, 0.999) per each one nmol/l increase in serum 25(OH) D concentration.ConclusionsLow serum 25(OH) D concentration in PLE dogs was significantly associated with poor outcome. Further studies are required to investigate the clinical efficacy of Vitamin D (cholecalciferol) as a potential therapeutic agent for dogs with PLE.

【 授权许可】

CC BY   
© The Author(s). 2017