Apoptosis-associated biomarkers in tuberculosis: promising for diagnosis and prognosis prediction

BMC Infectious Diseases

Research Article

Pan-Chyr Yang¹  Jann-Yuan Wang¹  Chia-Lin Hsu¹  Chong-Jen Yu¹  Li-Na Lee²  Chun-Ta Huang³  Chin-Chung Shu³  Ming-Fang Wu⁴  Shie-Liang Hsieh⁴ 

[1] Department of Internal Medicine, National Taiwan University Hospital, # 7, Chung-Shan South Road, 100, Taipei, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, # 7, Chung-Shan South Road, 100, Taipei, Taiwan;Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan;Department of Traumatology, National Taiwan University Hospital, Taipei, Taiwan;Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan;Institute of Clinical Medicine & Infection and Immunity Center, National Yang-Ming University, Taipei, Taiwan;

关键词: Apoptosis;    Decoy receptor 3;    Latent tuberculosis infection;    Lipoxin;    Prostaglandin E2;    Tuberculosis;   

DOI  :  10.1186/1471-2334-13-45

 received in 2012-08-19, accepted in 2013-01-24,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundApoptosis-associated biomarkers are rarely studied, especially their role in predicting the development of tuberculosis (TB) from latent TB infection and in prognostication.MethodsPatients with TB and interferon-gamma release assay (IGRA)-positive and IGRA-negative family contacts were evaluated to analyze changes in apoptosis-associated serum biomarkers, which included decoy receptor 3 (DcR3), prostaglandin 2 (PGE2), and lipoxin. The prognostic implications of these serum biomarkers were also analyzed.ResultsOne hundred TB patients and 92 IGRA-negative and 91 IGRA-positive family contacts were recruited. The DcR3 and PGE2 levels decreased from the IGRA-negative group to the IGRA-positive group, and peaked in the TB group. Lipoxin decreased to trough in the TB group. The three apoptosis serum markers and age were independent factors discriminating active TB from latent TB infection. In active TB, older age, co-morbidity, and higher serum DcR3 and monocyte chemotactic protein (MCP)-1 were independently associated with poorer six-month survival.ConclusionApoptosis-associated serum biomarkers change along with the status of Mycobacterium tuberculosis infection. In close contacts with positive IGRA, high DcR3 and PGE2 and low lipoxin may increase the probability of active TB. Older age, co-morbidity, and high DcR3 and MCP-1 levels might be important prognostic factors that warrant further investigation.

【 授权许可】

Unknown   
© Shu et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.