Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

BMC Infectious Diseases

Research Article

Martin Borggrefe¹  Michael Behnes¹  Siegfried Lang¹  Dominic Pauly¹  Ibrahim Akin¹  Max Barre¹  Sonja Hamed¹  Dominic Lepiorz¹  Ursula Hoffmann¹  Tobias Becher¹  Thomas Bertsch² 

[1] First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1–3, 68167, Mannheim, Germany;Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, General Hospital Nuremberg, Paracelsus Medical University, Nuremberg, Germany;

关键词: Sepsis;    Septic shock;    Pentraxin-3;    ICU;    Biomarkers;    Sepsis-3;   

DOI  :  10.1186/s12879-017-2606-3

 received in 2017-04-08, accepted in 2017-07-18,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU).MethodsThe study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8.ResultsPTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001).ConclusionPTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions.Trial registrationNCT01535534. Registered 14.02.2012

【 授权许可】

CC BY   
© The Author(s). 2017