Autologous formalin-fixed tumor vaccine suppressed re-recurrence of HCV-related hepatocellular carcinoma following 29 unsuccessful treatments with extensive conventional therapy: a case report

World Journal of Surgical Oncology

Case Report

Tadao Ohno¹  Toshio Inui² 

[1] Cell-Medicine, Inc., Sengen 2-1-6, 305-0047, Tsukuba Science City, Ibaraki, Japan;Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, 169-8555, Shinjuku-ku, Tokyo, Japan;Inui Cancer Immunotherapy Clinic, 6-14-17 Kinndachou, 570-0011, Moriguchi-shi, Osaka, Japan;

关键词: Tumor vaccine;    hepatocellular carcinoma;    suppression of re-recurrence;   

DOI  :  10.1186/1477-7819-10-144

 received in 2012-04-06, accepted in 2012-07-12,  发布年份 2012

来源: Springer

【 摘 要 】

Treatment of hepatocellular carcinoma (HCC) with autologous formalin-fixed tumor vaccine after primary resection has been shown to suppress the recurrence of hepatitis B virus-associated HCC, but the effect of this treatment on hepatitis C virus (HCV)-related disease has not yet been clarified. Here, we report a case of a patient with repeat recurrent HCC that was associated with HCV who had endured 29 episodes of HCC recurrence despite a variety of therapy using conventional methods. Finally, treatment with a single course of autologous formalin-fixed tumor vaccine resulted in suppression of potential further re-recurrence of HCC for more than 43 months without any additional treatment.

【 授权许可】

CC BY   
© Inui and Ohno; licensee BioMed Central Ltd. 2012