Reduced risk for placental malaria in iron deficient women

Malaria Journal

Research

Peter N Kazembe¹  Gibby Koshy²  Gregory Harper²  Bernard J Brabin³  Edward L Senga⁴ 

[1] Baylor College of Medicine Children's Foundation, Lilongwe, Malawi;Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK;Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK;Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam, the Netherlands;Department of Community Child Health, Royal Liverpool Children's Hospital NHS Trust Alder Hey, Liverpool, UK;University of Malawi College of Medicine, Biochemistry Department, Blantyre, Malawi;

关键词: Malaria;    Iron Deficiency;    Iron Status;    Malaria Risk;    Placental Malaria;   

DOI  :  10.1186/1475-2875-10-47

 received in 2010-09-16, accepted in 2011-02-23,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundNutritional iron deficiency may limit iron availability to the malaria parasite reducing infection risk, and/or impair host immunity thereby increasing this risk. In pregnant women, there is evidence of an adverse effect with iron supplementation, but the few reported studies are strongly confounded.MethodsA case control study in pregnant Malawian women was undertaken in Chikhwawa southern Malawi in order to describe iron status in relation to placental malaria controlling for several confounding factors. Pregnancy characteristics were obtained and a blood sample at delivery. A full blood count was performed and serum ferritin and transferrin receptor quantified by enzyme-linked immunoassay. DNA analysis was used to identify genetic polymorphisms for ABO phenotype, hemoglobin HbS, and glucose -6 phosphate dehydrogenase deficiency. Placental tissue was obtained and malaria histology classified as active, past or no malaria infection.Results112 cases with placental malaria were identified and 110 women with no evidence of placental infection. Iron deficiency was less frequent in women with placental Plasmodium falciparum infection. In those with acute, chronic or past placental infections the odds ratio for iron deficiency was 0.4, 95% CI 0.2-0.8, p = 0.01; for acute and chronic infections 0.4, 0.2-0.8, p = 0.006; for acute infection 0.3, 0.1-0.7, p = 0.001. The association was greater in multigravidae.ConclusionWomen with either acute, or acute and chronic placental malaria were less likely to have iron deficiency than women without placental malaria infection There is a priority to establish if reversing iron deficiency through iron supplementation programs either prior to or during pregnancy enhances malaria risk.

【 授权许可】

Unknown   
© Senga et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.