Very ‘sticky’ proteins – not too sticky after all?

Cell Communication and Signaling

Commentary

Stephan M Feller¹  Marc Lewitzky¹ 

[1] Biological Systems Architecture Group, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, OX3 9DS, Oxford, UK;

关键词: Intracellular Protein;    Protein Network;    Transport Infrastructure;    Holistic Picture;    Macromolecular Crowding;   

DOI  :  10.1186/1478-811X-10-15

 received in 2012-05-30, accepted in 2012-06-14,  发布年份 2012

来源: Springer

【 摘 要 】

A considerable number of soluble proteins in cells that biochemists try to analyze are difficult to handle because they seem to behave like sponges that ‘suck up’ many other proteins. We argue here that this behavior is commonly an artifact introduced by the experimenting scientist and that we need to study proteins like animals in the wild: they will only reveal many of their secrets when carefully observed in their largely undisturbed, natural environment. Computational studies that attempt to realistically model cellular protein networks must also factor in the diverse protein habitats to be found in cells.

【 授权许可】

CC BY   
© Feller and Lewitzky; licensee BioMed Central Ltd. 2012