Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso

Malaria Journal

Research

David Malone¹  Roger Sanou²  Abdoulaye Diabaté²  Severin N’do²  Abdoulaye Ouattara²  Roch K. Dabiré²  Moussa Namountougou³  Koama Bayili³  Anicet G. Ouédraogo³ 

[1] Innovative Vector Control Consortium/Liverpool, Liverpool, UK;Intitut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Burkina Faso;Intitut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Burkina Faso;Universite Polytechnique de Bobo, Bobo-Dioulasso, Burkina Faso;

关键词: Malaria;    Anopheles gambiae;    Chlorfenapyr;    Insecticide;    Bed net;    Pyrethroid resistance;   

DOI  :  10.1186/s12936-017-1846-4

 received in 2016-12-01, accepted in 2017-05-02,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMalaria vectors have acquired widespread resistance throughout sub-Saharan Africa to many of the currently used insecticides. Hence, there is an urgent need to develop alternative strategies including the development of new insecticides for effective management of insecticide resistance. To maintain progress against malaria, it is necessary to identify other residual insecticides for mosquito nets. In the present WHOPES phase II analogue study, the utility of chlorfenapyr, a pyrrole class insecticide mixed with alpha-cypermethrin on a long-lasting mosquito bed net was evaluated against Anopheles gambiae s.l.MethodsBed nets treated with chlorfenapyr and alpha-cypermethrin and mixture of both compounds were tested for their efficacy on mosquitoes. Washed (20 times) and unwashed of each type of treated nets and were tested according to WHOPES guidelines. Efficacy of nets were expressed in terms of blood-feeding inhibition rate, deterrence, induced exophily and mortality rate. The evaluation was conducted in experimental huts of Vallée du Kou seven (VK7) in Burkina Faso (West Africa) following WHOPES phase II guidelines. In addition, a WHOPES phase I evaluation was also performed.ResultsMixture treated nets killed significantly (P < 0.05) more mosquitoes than solo alpha-cypermethrin nets, unwashed and washed. Proportionally, this equated to mortalities of 78 and 76% (for mixture nets) compared to only 17 and 10% (for solo alpha-cypermethrin) to An. gambiae, respectively. In contrast mixture net proportions were not significantly (P > 0.05) different from nets treated with chlorfenapyr 200 mg/m2 unwashed (86%). The washed and unwashed nets treated with the mixtures resulted in personal protection against An. gambiae s.l. biting 34 and 44%. In contrast the personal protection observed for washed and unwashed alpha-cypermethrin treated nets generated (14 and 24%), and chlorfenapyr solo treated net was rather low (22%).ConclusionAmong all nets trialled, the combination of chlorfenapyr and alpha-cypermethrin on bed nets provided better mortality in phase II after 20 washes. Results suggest that this combination could be a potential insecticide resistance management tool for preventing malaria transmission in areas compromised by the spread of pyrethroid resistance.

【 授权许可】

CC BY   
© The Author(s) 2017