Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study

Environmental Health

Research

Joseph M. Braun¹  Meghan M. Woods²  Bruce P. Lanphear³  Lawrence C. McCandless⁴ 

[1] Department of Epidemiology, Brown University, Box G-S121-2, 121 South Main St, 02912, Providence, Rhode Island, USA;Faculty of Health Sciences, Simon Fraser University, Blusson Hall, Rm 11300, 8888 University Drive, V5A 1S6, Burnaby, British Columbia, Canada;Faculty of Health Sciences, Simon Fraser University, Blusson Hall, Rm 11300, 8888 University Drive, V5A 1S6, Burnaby, British Columbia, Canada;Child and Family Research Institute, BC Children’s and Women’s Hospital, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada;Faculty of Health Sciences, Simon Fraser University, Blusson Hall, Rm 11300, 8888 University Drive, V5A 1S6, Burnaby, British Columbia, Canada;Department of Statistics and Actuarial Science, University of British Columbia, Faculty of Science, 3182 Earth Science Building, 2207 Main Mall, V6T 1Z4, Vancouver, British Columbia, Canada;

关键词: Birth weight;    Endocrine disruptors;    Environmental exposure;    Maternal exposure;    Pregnancy;   

DOI  :  10.1186/s12940-017-0332-3

 received in 2017-03-01, accepted in 2017-10-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPregnant women are exposed to a mixture of endocrine disrupting chemicals (EDCs). Gestational EDC exposures may be associated with changes in fetal growth that elevates the risk for poor health later in life, but few studies have examined the health effects of simultaneous exposure to multiple chemicals. This study aimed to examine the association of gestational exposure to five chemical classes of potential EDCs: phthalates and bisphenol A, perfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) with infant birth weight.MethodsUsing data from the Health Outcomes and Measures of Environment (HOME) Study, we examined 272 pregnant women enrolled between 2003-2006. EDC concentrations were quantified in blood and urine samples collected at 16 and 26 weeks gestation. We used Bayesian Hierarchical Linear Models (BHLM) to examine the associations between newborn birth weight and 53 EDCs, 2 organochlorine pesticides (OPPs) and 2 heavy metals.ResultsFor a 10-fold increase in chemical concentration, the mean differences in birth weights (95% credible intervals (CI)) were 1 g (-20, 23) for phthalates, -11 g (-52, 34) for PFAS, 0.2 g (-9, 10) for PCBs, -4 g (-30, 22) for PBDEs, and 7 g (-25, 40) for OCPs.ConclusionGestational exposure to phthalates, PFAS, PCBs, PBDEs, OCPs or OPPs had null or small associations with birth weight. Gestational OPP, Pb, and PFAS exposures were most strongly associated with lower birth weight.

【 授权许可】

CC BY   
© The Author(s). 2017