Comparison of long and short axis quantification of left ventricular volume parameters by cardiovascular magnetic resonance, with ex-vivo validation

Journal of Cardiovascular Magnetic Resonance

Research

James Clarke¹  Matthias G Friedrich²  Michael Ma²  Myra Cocker²  Oliver Strohm²  Lucia Ma²  Helene Childs²  Jordin Green³ 

[1] Dept. of Nuclear Medicine and Radiology, Dalhousie University, Halifax, NC, Canada;Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Departments of Cardiac Sciences and Radiology, University of Calgary, AB, Canada;Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Departments of Cardiac Sciences and Radiology, University of Calgary, AB, Canada;Siemens Healthcare, Henkestr, 12791054, Erlangen, Germany;

关键词: Cardiovascular Magnetic Resonance;    Left Ventricular Mass;    Papillary Muscle;    Left Ventricular Volume;    Left Ventricular Outflow Tract;   

DOI  :  10.1186/1532-429X-13-40

 received in 2011-04-12, accepted in 2011-08-11,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe purpose of the study was to compare the accuracy and evaluation time of quantifying left ventricular (LV), left atrial (LA) volume and LV mass using short axis (SAX) and long axis (LAX) methods when using cardiovascular magnetic resonance (CMR).Materials and methodsWe studied 12 explanted canine hearts and 46 patients referred for CMR (29 male, age 47 ± 18 years) in a clinical 1.5 T CMR system, using standard cine sequences. In standard short axis stacks of various slice thickness values in dogs and 8 mm slice thickness (gap 2 mm) in patients, we measured LV volumes using reference slices in a perpendicular, long axis orientation using certified software. Volumes and mass were also measured in six radial long axis (LAX) views.LV parameters were also assessed for intra- and inter-observer variability. In 24 patients, we also analyzed reproducibility and evaluation time of two very experienced (> 10 years of CMR reading) readers for SAX and LAX.ResultsIn the explanted dog hearts, there was excellent agreement between ex vivo data and LV mass and volume data as measured by all methods for both, LAX (r2 = 0.98) and SAX (r2 = 0.88 to 0.98). LA volumes, however, were underestimated by 13% using the LAX views. In patients, there was a good correlation between all three assessed methods (r2 ≥ 0.95 for all). In experienced clinical readers, left-ventricular volumes and ejection fraction as measured in LAX views showed a better inter-observer reproducibility and a 27% shorter evaluation time.ConclusionWhen compared to an ex vivo standard, both, short axis and long axis techniques are highly accurate for the quantification of left ventricular volumes and mass. In clinical settings, however, the long axis approach may be more reproducible and more time-efficient. Therefore, the rotational long axis approach is a viable alternative for the clinical assessment of cardiac volumes, function and mass.

【 授权许可】

Unknown   
© Childs et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.