Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells

BMC Immunology

Research Article

Knut Liseth¹  Elisabeth Ersvaer²  Jørn Skavland²  Øystein Bruserud³  Bjørn Tore Gjertsen³ 

[1] Department of Medicine, Haukeland University Hospital, Bergen, Norway;Institute of Medicine, University of Bergen, Bergen, Norway;Institute of Medicine, University of Bergen, Bergen, Norway;Department of Medicine, Haukeland University Hospital, Bergen, Norway;

关键词: Acute Myeloid Leukemia;    TREG Cell;    Acute Myeloid Leukemia Patient;    Acute Myeloid Leukemia Cell;    Untreated Disease;   

DOI  :  10.1186/1471-2172-11-38

 received in 2010-02-01, accepted in 2010-07-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundSeveral observations suggest that immunological events early after chemotherapy, possibly during the period of severe treatment-induced cytopenia, are important for antileukemic immune reactivity in acute myeloid leukemia (AML). We therefore investigated the frequencies of various T cell subsets (TC1, TH1, TH17) and CD25+ FoxP3+ TREG cells in AML patients with untreated disease and following intensive chemotherapy.ResultsRelative levels of circulating TC1 and TH1 cells were decreased in patients with severe chemotherapy-induced cytopenia, whereas TH17 levels did not differ from healthy controls. Increased levels of regulatory CD25+ FoxP3+ T cells were detected in AML patients with untreated disease, during chemotherapy-induced cytopenia and during regeneration after treatment. TH17 and TH1 levels were significantly higher in healthy males than females, but this gender difference was not detected during chemotherapy-induced cytopenia. Finally, exogenous IL17-A usually had no or only minor effects on proliferation of primary human AML cells.ConclusionsWe conclude that the effect of intensive AML chemotherapy differ between circulating T cell subsets, relative frequencies of TH17 cells are not affected by chemotherapy and this subset may affect AML cells indirectly through their immunoregulatory effects but probably not through direct effects of IL17-A.

【 授权许可】

CC BY   
© Ersvaer et al; licensee BioMed Central Ltd. 2010