A complete response to mFOLFOX6 and panitumumab chemotherapy in advanced stage rectal adenocarcinoma: a case report

World Journal of Surgical Oncology

Case Report

Mitsuaki Ishida¹  Tohru Tani²  Tomoharu Shimizu²  Eiji Mekata²  Hiromichi Sonoda²  Yoshihiro Endo² 

[1] Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, 520-2192, Shiga, Japan;Department of Surgery, Shiga University of Medical Science,, Seta Tsukinowa-cho, Otsu, 520-2192, Shiga, Japan;

关键词: Neoadjuvant chemotherapy;    Rectal cancer;    Panitumumab;   

DOI  :  10.1186/1477-7819-12-63

 received in 2013-04-26, accepted in 2014-03-15,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPathological complete remission of advanced stage rectal adenocarcinoma by chemotherapy alone is rare. A case of advanced stage, low-lying rectal adenocarcinoma in which a complete response to treatment was obtained with mFOLFOX6 and panitumumab (Pmab) is reported.Case presentationA 53-year-old man was referred to Shiga University of Medical Science hospital Shiga, Japan, complaining of bloody stool. Gastrointestinal endoscopy was performed, and advanced stage rectal adenocarcinoma was diagnosed. Computed tomography (CT) revealed regional lymph node metastases in the mesorectum. Neoadjuvant chemotherapy (NAC) with mFOLFOX6 and Pmab was planned.Endoscopy following four courses of chemotherapy revealed that the rectal cancer had been markedly reduced, and the results of biopsies of the rectal tumor were negative for cancer. On CT, the mesorectal lymph node metastases had disappeared. Total intersphincteric resection (ISR) with a handsewn coloanal anastomosis was performed. Histological examination showed a complete response to mFOLFOX6 and Pmab in advanced stage rectal cancer.ConclusionThe result seen in this case suggests that short-term NAC with mFOLFOX6 and Pmab was effective for low-lying rectal adenocarcinoma.

【 授权许可】

CC BY   
© Sonoda et al.; licensee BioMed Central Ltd. 2014