Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension

Journal of Cardiovascular Magnetic Resonance

Research

Jamie Dunning¹  Craig Lanning¹  Shawna Burgett¹  Kendall Hunter¹  Alex J Barker²  D Dunbar Ivy³  Brian Fonseca³  Uyen Truong³  Robin Shandas⁴ 

[1] Department for Bioengineering, University of Colorado, 13123 E. 16th Avenue B100, 80045, Aurora, CO, USA;Department of Radiology, Feinberg School of Medicine, Northwestern University, 60611, Chicago, IL, USA;Division of Pediatric Cardiology, Children’s Hospital Colorado, 80045, Aurora, CO, USA;Division of Pediatric Cardiology, Children’s Hospital Colorado, 80045, Aurora, CO, USA;Department for Bioengineering, University of Colorado, 13123 E. 16th Avenue B100, 80045, Aurora, CO, USA;

关键词: Vessel size;    Pulmonary hypertension;    Wall shear stress;    Cardiovascular magnetic resonance;   

DOI  :  10.1186/1532-429X-15-81

 received in 2013-05-13, accepted in 2013-09-03,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPulmonary arterial hypertension (PAH) is a devastating disease with significant morbidity and mortality. At the macroscopic level, disease progression is observed as a complex interplay between mean pulmonary artery pressure, pulmonary vascular resistance, pulmonary vascular stiffness, arterial size, and flow. Wall shear stress (WSS) is known to mediate or be dependent on a number of these factors. Given that WSS is known to promote architectural vessel remodeling, it is imperative that the changes of this factor be quantified in the presence of PAH.MethodsIn this study, we analyzed phase contrast imaging of the right pulmonary artery derived from cardiovascular magnetic resonance to quantify the local, temporal and circumferentially averaged WSS of a PAH population and a pediatric control population. In addition, information about flow and relative area change were derived.ResultsAlthough the normotensive and PAH shear waveform exhibited a WSS profile which is uniform in magnitude and direction along the vessel circumference at systole, time-averaged WSS (2.2 ± 1.6 vs. 6.6 ± 3.4 dynes/cm2, P = 0.018) and systolic WSS (8.2 ± 5.0 v. 20.0 ± 9.1 dynes/cm2, P = 0.018) was significantly depressed in the PAH population as compared to the controls. BSA-indexed PA diameter was significantly larger in the PAH population (1.5 ± 0.4 vs. 0.7 ± 0.1 cm/m2, P = 0.003).ConclusionsIn the presence of preserved flow rates through a large PAH pulmonary artery, WSS is significantly decreased. This may have implications for proximal pulmonary artery remodeling and cellular function in the progression of PAH.

【 授权许可】

Unknown   
© Truong et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.