Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice

Journal of Biomedical Science

Review

Mika Takai¹  Yasushi Fujio¹  Yasushi Kimura¹  Shohei Oishi¹  Yoriko Uozumi¹  Stephen W Schaffer²  Takashi Ito³  Junichi Azuma³ 

[1] Department of Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan;Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA;Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan;

关键词: Taurine;    Dilate Cardiomyopathy;    Brain Natriuretic Peptide;    Atrial Natriuretic Peptide;    Taurine Level;   

DOI  :  10.1186/1423-0127-17-S1-S20

来源: Springer

【 摘 要 】

Taurine, a sulfur-containing β-amino acid, is highly contained in heart and skeletal muscle. Taurine has a variety of biological actions, such as ion movement, calcium handling and cytoprotection in the cardiac and skeletal muscles. Meanwhile, taurine deficiency leads various pathologies, including dilated cardiomyopathy, in cat and fox. However, the essential role of taurine depletion on pathogenesis has not been fully clarified. To address the physiological role of taurine in mammalian tissues, taurine transporter-(TauT-) knockout models were recently generated. TauTKO mice exhibited loss of body weight, abnormal cardiac function and the reduced exercise capacity with tissue taurine depletion. In this chapter, we summarize pathological profile and histological feature of heart and skeletal muscle in TauTKO mice.

【 授权许可】

CC BY   
© Azuma et al; licensee BioMed Central Ltd. 2010