A gene-based approach for testing association of rare alleles

BMC Proceedings

Proceedings

Varghese George¹  Hongyan Xu¹ 

[1] Department of Biostatistics, Georgia Health Sciences University, 1120 15th Street, 30912, Augusta, GA, USA;

关键词: Rare Allele;    Power Estimate;    Association Method;    Null Gene;    Rare Genetic Variant;   

DOI  :  10.1186/1753-6561-5-S9-S7

来源: Springer

【 摘 要 】

Rare genetic variants have been shown to be important to the susceptibility of common human diseases. Methods for detecting association of rare genetic variants are drawing much attention. In this report, we applied a gene-based approach to the 200 simulated data sets of unrelated individuals. The test can detect the association of some genes with multiple rare variants.

【 授权许可】

CC BY   
© Xu and George; licensee BioMed Central Ltd. 2011