Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements

Nutrition Journal

Research

Andrei M Komarov¹  Garry R Buettner²  Jeremy S Ivie³  Alexander B Rabovsky³ 

[1] Department of Biochemistry and Molecular Biology, The George Washington University, 20037, Washington, D.C., USA;Free Radical and Radiation Biology, The University of Iowa, 52242, Iowa City, IA, USA;Research & Technology Development, Melaleuca Inc., 83402, Idaho Falls, ID, USA;

关键词: Inulin;    Trolox;    Copper Sulfate;    Oxidative Flux;    Redox Active Metal;   

DOI  :  10.1186/1475-2891-9-61

 received in 2010-06-10, accepted in 2010-11-23,  发布年份 2010

来源: Springer

【 摘 要 】

Multivitamin/multimineral complexes are the most common dietary supplements. Unlike minerals in foods that are incorporated in bioorganic structures, minerals in dietary supplements are typically in an inorganic form. These minerals can catalyze the generation of free radicals, thereby oxidizing antioxidants during digestion. Here we examine the ability of a matrix consisting of an amino acid and non-digestible oligosaccharide (AAOS) to blunt metal-catalyzed oxidations. Monitoring of ascorbate radical generated by copper shows that ascorbate is oxidized more slowly with the AAOS matrix than with copper sulfate. Measurement of the rate of oxidation of ascorbic acid and Trolox® by catalytic metals confirmed the ability of AAOS to slow these oxidations. Similar results were observed with iron-catalyzed formation of hydroxyl radicals. When compared to traditional forms of minerals used in supplements, we conclude that the oxidative loss of antioxidants in solution at physiological pH is much slower when AAOS is present.

【 授权许可】

CC BY   
© Rabovsky et al; licensee BioMed Central Ltd. 2010