Characteristics of asymptomatic Plasmodium spp. parasitaemia in Kwahu-Mpraeso, a malaria endemic mountainous district in Ghana, West Africa

Malaria Journal

Research

Martin P. Grobusch¹  Ewurama D. A. Owusu²  Petra Mens³  Charles A. Brown⁴  Samuel Dadzie⁵  Vincent Buabeng⁶ 

[1] Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Centre, Centre of Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, The Netherlands;Centre de Recherches Médicales de Lambaréné (CERMEL), Hôpital Albert Schweitzer, Lambaréné, Gabon;Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany;Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Centre, Centre of Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, The Netherlands;Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana;Department of Parasitology, KIT Biomedical Research Institute, Amsterdam, The Netherlands;Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Centre, Centre of Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, The Netherlands;Department of Parasitology, KIT Biomedical Research Institute, Amsterdam, The Netherlands;Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana;Medical Entomology Unit, Department of Parasitology, Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana;Medical Laboratory Department, Atibie Government Hospital, Kwahu-Atibie, Ghana;

关键词: Asymptomatic malaria;    Plasmodium;    Highland;    Ghana;    Sickle cell trait;    Anopheles gambiae;   

DOI  :  10.1186/s12936-015-1066-8

 received in 2015-07-14, accepted in 2015-12-22,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMalaria control efforts in Ghana have reduced the countrywide average malaria prevalence from 71 % in 2000 to about 51 % in 2012; however, its main focus is on symptomatic malaria. If further progress is to be made, parasite reservoirs in asymptomatic carriers need to be moved into focus. This study profiles asymptomatic Plasmodium spp. parasitaemia amongst residents of mountainous Kwahu-Mpraeso in the Eastern region of Ghana.MethodsA cross-sectional study of 360 residents was carried out from October to December 2013. This included recording demographics, malaria testing of asymptomatic residents, and gathering of their malaria history. Assessment of malaria transmission was done with molecular identification of vectors, determination of sporozoite rate, insecticide resistance status and biting pattern. Univariate and multivariate analysis were used to establish risk determinants.ResultsIn Mpraeso, in the Kwahu highland of Eastern Region, children were at higher risk of asymptomatic parasitaemia, thereby contributing to the parasite reservoir and hence sustained malaria transmission. As well, findings suggested Hb AC genotype influenced susceptibility to asymptomatic malaria with 8.03-fold increase in odds (univariate) and 11.92-fold higher odds (multivariate) than the normal Hb AA. The mosquito vector predominant in the area was Anopheles gambiae sensu stricto of the homozygous pyrethroid resistant form (RR); with biting mainly occurring indoors.ConclusionFor an effective malaria control in this area, interventions should be formulated and implemented to target asymptomatic parasite reservoirs; especially in children and people with Hb AC. The dominant vector species An. gambiae s.s. and its feeding patterns of biting indoors should also be considered.

【 授权许可】

CC BY   
© Owusu et al. 2016