Including pork in the Mediterranean diet for an Australian population: Protocol for a randomised controlled trial assessing cardiovascular risk and cognitive function

Nutrition Journal

Study Protocol

Kathryn A. Dyer¹  Courtney R. Davis¹  Alexandra T. Wade¹  Karen J. Murphy¹  Hannah A. D. Keage²  Richard J. Woodman³  Jonathan M. Hodgson⁴ 

[1] Alliance for Research in Exercise, Nutrition and Activity, School of Health Sciences, University of South Australia, GPO Box 2471, 5001, Adelaide, South Australia, Australia;Cognitive Ageing and Impairment Neurosciences, School of Psychology, Social Work and Social Policy, University of South Australian, GPO Box 2471, 5001, Adelaide, SA, Australia;Flinders Centre for Epidemiology and Biostatistics, Flinders University, GPO Box 2100, 5001, Adelaide, South Australia, Australia;School of Medicine and Pharmacology, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, 35 Stirling Highway, 6000, Perth, WA, Australia;School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia;

关键词: Mediterranean diet;    CVD;    Cognitive function;    Randomised controlled trial;   

DOI  :  10.1186/s12937-017-0306-x

 received in 2017-09-14, accepted in 2017-11-29,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe Mediterranean diet is characterised by the high consumption of extra virgin olive oil, fruits, vegetables, grains, legumes and nuts; moderate consumption of fish, poultry, eggs and dairy; and low consumption of red meat and sweets. Cross sectional, longitudinal and intervention studies indicate that a Mediterranean diet may be effective for the prevention of cardiovascular disease and dementia. However, previous research suggests that an Australian population may find red meat restrictions difficult, which could affect long term sustainability of the diet.MethodsThis paper outlines the protocol for a randomised controlled trial that will assess the cardiovascular and cognitive benefits of a Mediterranean diet modified to include 2-3 weekly serves of fresh, lean pork. A 24-week cross-over design trial will compare a modified Mediterranean diet with a low-fat control diet in at-risk men and women. Participants will follow each of the two diets for 8 weeks, with an 8-week washout period separating interventions. Home measured systolic blood pressure will be the primary outcome measure. Secondary outcomes will include body mass index, body composition, fasting blood lipids, C-reactive protein, fasting plasma glucose, fasting serum insulin, erythrocyte fatty acids, cognitive function, psychological health and well-being, and dementia risk.DiscussionTo our knowledge this research is the first to investigate whether an alternate source of protein can be included in the Mediterranean diet to increase sustainability and feasibility for a non-Mediterranean population. Findings will be significant for the prevention of cardiovascular disease and age-related decline, and may inform individuals, clinicians and public health policy.Trial registrationACTRN12616001046493. Registered 5 August 2016.

【 授权许可】

CC BY   
© The Author(s). 2017