Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases

Malaria Journal

Review

Sameena Khan¹ 

[1] Drug Discovery Research Centre, Translational Health Science and Technology Institute (THSTI), NCR Biotech Science Cluster, PO box #04, 3rd Milestone, Faridabad-Gurgaon Expressway, 121001, Faridabad, India;

关键词: Malaria Parasite;    High Content Screening;    Asexual Blood Stage;    tRNA Binding;    Editing Domain;   

DOI  :  10.1186/s12936-016-1247-0

 received in 2015-12-01, accepted in 2016-03-30,  发布年份 2016

来源: Springer

【 摘 要 】

Escalating drug resistance in malaria parasites and lack of vaccine entails the discovery of novel drug targets and inhibitor molecules. The multi-component protein translation machinery is a rich source of such drug targets. Malaria parasites contain three translational compartments: the cytoplasm, apicoplast and mitochondrion, of which the latter two are of the prokaryotic type. Recent explorations by many groups into the malaria parasite protein translation enzymes, aminoacyl-tRNA synthetases (aaRSs), have yielded many promising inhibitors. The understanding of the biology of this unique set of 36 enzymes has become much clearer in recent times. Current review discusses the advances made in understanding of crucial aaRSs from Plasmodium and also the specific inhibitors found against malaria aaRSs.

【 授权许可】

CC BY   
© Khan. 2016