Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies

BMC Cancer

Research Article

Mei Xiao¹  Hua-Ying Fang¹  Ye-Tao Wang¹  Ya-Wen Gou¹  Wen-Wen Jin¹ 

[1] Department of gastroenterology, Anhui provincial hospital, NO.17, Lujiang Road, 230001, Hefei City, Anhui Province, China;

关键词: Alcohol;    Pancreatic cancer;    Meta-analysis;   

DOI  :  10.1186/s12885-016-2241-1

 received in 2014-11-30, accepted in 2016-03-01,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundStudies examining the association between alcohol intake and the risk of pancreatic cancer have given inconsistent results. The purpose of this study was to summarize and examine the evidence regarding the association between alcohol intake and pancreatic cancer risk based on results from prospective cohort studies.MethodsWe searched electronic databases consisting of PubMed, Ovid, Embase, and the Cochrane Library identifying studies published up to Aug 2015. Only prospective studies that reported effect estimates with 95 % confidence intervals (CIs) for the risk of pancreatic cancer, examining different alcohol intake categories compared with a low alcohol intake category were included. Results of individual studies were pooled using a random-effects model.ResultsWe included 19 prospective studies (21 cohorts) reporting data from 4,211,129 individuals. Low-to-moderate alcohol intake had little or no effect on the risk of pancreatic cancer. High alcohol intake was associated with an increased risk of pancreatic cancer (risk ratio [RR], 1.15; 95 % CI: 1.06–1.25). Pooled analysis also showed that high liquor intake was associated with an increased risk of pancreatic cancer (RR, 1.43; 95 % CI: 1.17–1.74). Subgroup analyses suggested that high alcohol intake was associated with an increased risk of pancreatic cancer in North America, when the duration of follow-up was greater than 10 years, in studies scored as high quality, and in studies with adjustments for smoking status, body mass index, diabetes mellitus, and energy intake..ConclusionsLow-to-moderate alcohol intake was not significantly associated with the risk of pancreatic cancer, whereas high alcohol intake was associated with an increased risk of pancreatic cancer. Furthermore, liquor intake in particular was associated with an increased risk of pancreatic cancer.

【 授权许可】

CC BY   
© Wang et al. 2016