Viral and bacterial etiology of severe acute respiratory illness among children < 5 years of age without influenza in Niger

BMC Infectious Diseases

Research Article

Halima Boubacar Maïnassara¹  Bassira Issaka¹  Adamou Lagare¹  Ali Sidiki¹  Stefano Tempia² 

[1] Centre de Recherche Médicale et Sanitaire (CERMES), BP:10887, 634 Bld de la Nation, YN034-, Niamey, Niger;Influenza Division, Centers for Disease Control and Prevention, Georgia, Atlanta, USA;Influenza Program, Centers for Disease Control and Prevention, Pretoria, South Africa;

关键词: Niger;    Severe acute respiratory illness;    Virus;    Bacteria;    Etiology;   

DOI  :  10.1186/s12879-015-1251-y

 received in 2015-03-05, accepted in 2015-10-28,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundGlobally, pneumonia is the leading cause of morbidity and mortality in children, with the highest burden experienced in sub-Saharan Africa and Asia. However, there is a dearth of information on the etiology of severe acute respiratory illness (SARI) in Africa, including Niger.MethodsWe implemented a retrospective study as part of national influenza sentinel surveillance in Niger. We randomly selected a sample of nasopharyngeal specimens collected from children <5 years of age hospitalized with SARI from January 2010 through December 2012 in Niger. The samples were selected from individuals that tested negative by real-time reverse transcription polymerase chain reaction (rRT-PCR) for influenza A and B virus. The samples were analyzed using the Fast Track Diagnostic Respiratory Pathogens 21plus Kit (BioMérieux, Luxemburg), which detects 23 respiratory pathogens including 18 viral and 5 bacterial agents.ResultsAmong the 160 samples tested, 138 (86 %) tested positive for at least one viral or bacterial pathogen; in 22 (16 %) sample, only one pathogen was detected. We detected at least one respiratory virus in 126 (78 %) samples and at least one bacterium in 102 (64 %) samples. Respiratory syncytial virus (56/160; 35 %), rhinovirus (47/160; 29 %) and parainfluenza virus (39/160; 24 %) were the most common viral pathogens detected. Among bacterial pathogens, Streptococcus pneumoniae (90/160; 56 %) and Haemophilus influenzae type b (20/160; 12 %) predominated.ConclusionsThe high prevalence of certain viral and bacterial pathogens among children <5 years of age with SARI highlights the need for continued and expanded surveillance in Niger.

【 授权许可】

CC BY   
© Lagare et al. 2015