Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

Lipids in Health and Disease

Review

Xiaolin Li¹  Nannan Zhang¹  Quanyong Dong¹  Xin Xu¹  Yongning Xin²  Shiying Xuan²  Linlin Lu³ 

[1] Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China;Digestive Disease Key Laboratory of Qingdao, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China;Digestive Disease Key Laboratory of Qingdao, Qingdao, China;Central Laboratories, Qingdao Municipal Hospital, Qingdao, China;Digestive Disease Key Laboratory of Qingdao, Qingdao, China;Central Laboratories, Qingdao Municipal Hospital, Qingdao, China;

关键词: Nonalcoholic fatty liver disease;    Atherosclerosis;    Insulin resistance;    Metabolic syndrome;    Cardiovascular disease;   

DOI  :  10.1186/s12944-015-0141-z

 received in 2015-05-20, accepted in 2015-10-22,  发布年份 2015

来源: Springer

【 摘 要 】

Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.

【 授权许可】

CC BY   
© Xu et al. 2015