In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice

BMC Gastroenterology

Research Article

Chi-Wai Cheung¹  Jian-Gang Song²  Cai-Yang Chen²  Kun-Ming Tao²  Wei-Feng Yu²  Li-Qun Yang²  Wu-Rong Chen³  Hong-Mei Ren³  Zhi-Qiang Liu⁴ 

[1] Department of Anaesthesiology, University of Hong Kong, Hong Kong, China;Department of Anesthesia and Intensive Care, Eastern Hepatobiliary Surgical Hospital, the Second Military Medical University, Shanghai, China;Department of Anesthesia, Putuo Hospital, Shanghai, China;Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China;

关键词: Obstructive Jaundice;    Mitochondrial Permeability Transition Pore;    Multiple Organ Dysfunction Syndrome;    Bile Duct Ligation;    Myocardial Performance;   

DOI  :  10.1186/1471-230X-11-144

 received in 2011-06-07, accepted in 2011-12-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundResponsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.MethodsMale Sprague-Dawley rats (n = 40) were randomly allocated into two groups, twenty underwent bile duct ligation (BDL), and 20 underwent a sham operation. Seven days after the surgery, propofol was administered in vivo and ex vivo (Langendorff preparations). Heart rate, left ventricular end-systolic pressure (LVESP) left ventricular end-diastolic pressure (LVEDP), and maximal rate for left ventricular pressure rise and decline (± dP/dtmax ) were measured to determine the influence of propofol on the cardiac function of rats.ResultsImpaired basal cardiac function was observed in the isolated BDL hearts, whereas in vivo indices of basal cardiac function (LVESP and ± dP/dt) in vivo were significantly higher in rats that underwent BDL compared with controls. With low or intermediate concentrations of propofol, these indices of cardiac function were within the normal physiologic range in both groups, and responsiveness to propofol was unaffected by BDL. When the highest concentration of propofol was administrated, a significant decline in cardiac function was observed in the BDL group.ConclusionsIn rats that underwent BDL, basal cardiac performance was better in vivo and worse ex vivo compared with controls. Low and intermediate concentrations of propofol did not appear to impair cardiac function in rats with obstructive jaundice.

【 授权许可】

Unknown   
© Ren et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.