Cellulases and beyond: the first 70 years of the enzyme producer Trichoderma reesei

Microbial Cell Factories

Review

Robert H. Bischof¹  Bernhard Seiboth²  Jonas Ramoni³ 

[1] Austrian Centre of Industrial Biotechnology (ACIB) GmbH c/o Institute of Chemical Engineering, TU Wien, Gumpendorferstraße 1a, 1060, Vienna, Austria;Austrian Centre of Industrial Biotechnology (ACIB) GmbH c/o Institute of Chemical Engineering, TU Wien, Gumpendorferstraße 1a, 1060, Vienna, Austria;Molecular Biotechnology, Research Area Biochemical Technology, Institute of Chemical Engineering, TU Wien, Gumpendorferstraße 1a, 1060, Vienna, Austria;Molecular Biotechnology, Research Area Biochemical Technology, Institute of Chemical Engineering, TU Wien, Gumpendorferstraße 1a, 1060, Vienna, Austria;

关键词: Trichoderma reesei;    Cellulase;    Recombinant protein production;    Biorefinery;    Lignocellulose;    Gene expression;    Consolidated bioprocessing;   

DOI  :  10.1186/s12934-016-0507-6

 received in 2016-03-03, accepted in 2016-06-01,  发布年份 2016

来源: Springer

【 摘 要 】

More than 70 years ago, the filamentous ascomycete Trichoderma reesei was isolated on the Solomon Islands due to its ability to degrade and thrive on cellulose containing fabrics. This trait that relies on its secreted cellulases is nowadays exploited by several industries. Most prominently in biorefineries which use T. reesei enzymes to saccharify lignocellulose from renewable plant biomass in order to produce biobased fuels and chemicals. In this review we summarize important milestones of the development of T. reesei as the leading production host for biorefinery enzymes, and discuss emerging trends in strain engineering. Trichoderma reesei has very recently also been proposed as a consolidated bioprocessing organism capable of direct conversion of biopolymeric substrates to desired products. We therefore cover this topic by reviewing novel approaches in metabolic engineering of T. reesei.

【 授权许可】

CC BY   
© The Author(s) 2016