Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

Lipids in Health and Disease

Review

Leonardo R Silveira¹  Amanda R Martins¹  Marco A Vinolo¹  Renato T Nachbar¹  Rui Curi¹  William T Festuccia¹  Sandro M Hirabara²  Renata Gorjao³  Rafael H Lambertucci³  Maria F Cury-Boaventura³ 

[1] Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Professor Lineu Prestes, 1524, Butantã, 05508-000, São Paulo, SP, Brazil;Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Professor Lineu Prestes, 1524, Butantã, 05508-000, São Paulo, SP, Brazil;Post-Graduate Program in Human Movement Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, São Paulo, SP, Brazil;Post-Graduate Program in Human Movement Sciences, Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, São Paulo, SP, Brazil;

关键词: Skeletal muscle;    Insulin resistance;    Saturated fatty acids;    Mitochondrial dysfunction;   

DOI  :  10.1186/1476-511X-11-30

 received in 2012-01-04, accepted in 2012-02-23,  发布年份 2012

来源: Springer

【 摘 要 】

Insulin resistance condition is associated to the development of several syndromes, such as obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking insulin resistance to these syndromes are not precisely defined yet, evidence suggests that the elevated plasma free fatty acid (FFA) level plays an important role in the development of skeletal muscle insulin resistance. Accordantly, in vivo and in vitro exposure of skeletal muscle and myocytes to physiological concentrations of saturated fatty acids is associated with insulin resistance condition. Several mechanisms have been postulated to account for fatty acids-induced muscle insulin resistance, including Randle cycle, oxidative stress, inflammation and mitochondrial dysfunction. Here we reviewed experimental evidence supporting the involvement of each of these propositions in the development of skeletal muscle insulin resistance induced by saturated fatty acids and propose an integrative model placing mitochondrial dysfunction as an important and common factor to the other mechanisms.

【 授权许可】

Unknown   
© Martins et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.