Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

Cardiovascular Diabetology

Review

Fadi G. Akar¹  Wonjoon Koh¹  Basil S. Karam¹  Alejandro Chavez-Moreno¹  Joseph G. Akar² 

[1] Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA;Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA;

关键词: Atrial fibrillation;    Diabetes;    Oxidative stress;    Electrical remodeling;    Fibrosis;   

DOI  :  10.1186/s12933-017-0604-9

 received in 2017-05-30, accepted in 2017-09-22,  发布年份 2017

来源: Springer

【 摘 要 】

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation.

【 授权许可】

CC BY   
© The Author(s) 2017