Accuracy of left ventricular ejection fraction by contemporary multiple gated acquisition scanning in patients with cancer: comparison with cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Research

Prabhjot S. Nijjar¹  Jeffrey R. Misialek¹  Felipe Kazmirczak¹  Chetan Shenoy¹  Hans Huang²  Afshin Farzaneh-Far³  Anne Blaes⁴  Igor Klem⁵  Nicholas P. Derrico⁶ 

[1] Cardiovascular Division, Department of Medicine, University of Minnesota Medical Center, 420 Delaware Street SE, MMC 508, 55455, Minneapolis, MN, USA;Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA;Division of Cardiology, Duke University Medical Center, Durham, NC, USA;Division of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA;Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA;Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC, USA;Division of Cardiology, Duke University Medical Center, Durham, NC, USA;University of Minnesota Medical School, Minneapolis, MN, USA;

关键词: Cardiovascular magnetic resonance;    MUGA;    Cancer;    Ejection fraction;    Onco-cardiology;    Cardio-oncology;   

DOI  :  10.1186/s12968-017-0348-4

 received in 2016-12-21, accepted in 2017-02-24,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMultiple gated acquisition scanning (MUGA) is a common imaging modality for baseline and serial assessment of left ventricular ejection fraction (LVEF) for cardiotoxicity risk assessment prior to, surveillance during, and surveillance after administration of potentially cardiotoxic cancer treatment. The objective of this study was to compare the accuracy of left ventricular ejection fractions (LVEF) obtained by contemporary clinical multiple gated acquisition scans (MUGA) with reference LVEFs from cardiovascular magnetic resonance (CMR) in consecutive patients with cancer.MethodsIn a cross-sectional study, we compared MUGA clinical and CMR reference LVEFs in 75 patients with cancer who had both studies within 30 days. Misclassification was assessed using the two most common thresholds of LVEF used in cardiotoxicity clinical studies and practice: 50 and 55%.ResultsCompared to CMR reference LVEFs, MUGA clinical LVEFs were only lower by a mean of 1.5% (48.5% vs. 50.0%, p = 0.17). However, the limits of agreement between MUGA clinical and CMR reference LVEFs were wide at −19.4 to 16.5%. At LVEF thresholds of 50 and 55%, there was misclassification of 35 and 20% of cancer patients, respectively.ConclusionsMUGA clinical LVEFs are only modestly accurate when compared with CMR reference LVEFs. These data have significant implications on clinical research and patient care of a population with, or at risk for, cardiotoxicity.

【 授权许可】

CC BY   
© The Author(s). 2017