Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers

Respiratory Research

Review

Lars C. Huber¹  Christian Benden²  Macé M. Schuurmans²  Nicole E. Speck²  Cécile A. Robinson² 

[1] Clinic for Internal Medicine, City Hospital Triemli, Birmensdorferstrasse 497, CH-8063, Zurich, Switzerland;Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland;

关键词: Blood;    Bronchoalveolar lavage;    Cytokine;    Diagnosis;    Graft rejection;    Lung transplantation;    Plasma;   

DOI  :  10.1186/s12931-017-0634-6

 received in 2017-05-11, accepted in 2017-08-02,  发布年份 2017

来源: Springer

【 摘 要 】

The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after lung transplantation. While these profiles might facilitate the diagnosis of acute cellular rejection, low sensitivity and specificity of these patterns limit direct translation in a clinical setting. In this context, the identification of other biomarkers is needed. This review article gives an overview of cytokine profiles of plasma and bronchoalveolar lavage samples during acute cellular rejection. The value of these cytokines in supporting the diagnosis of acute cellular rejection is discussed. Current findings on the topic are highlighted and experimental settings for future research projects are identified.

【 授权许可】

CC BY   
© The Author(s). 2017