Obstetric outcome in donor oocyte pregnancies: a matched-pair analysis

Reproductive Biology and Endocrinology

Research

Dominic Stoop¹  Michel Camus¹  Miriam Baumgarten¹  Nikolaos P Polyzos¹  Greta Verheyen¹  Patrick Haentjens¹  Michel De Vos¹  Paul Devroey¹ 

[1] Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B-1090, Brussels, Belgium;

关键词: Oocyte donation;    Pregnancy outcome;    Pregnancy-induced hypertension;    First trimester bleeding;   

DOI  :  10.1186/1477-7827-10-42

 received in 2012-01-06, accepted in 2012-05-04,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTo investigate the obstetrical and perinatal impact of oocyte donation, a cohort of women who conceived after OD was compared with a matched control group of women who became pregnant through in vitro fertilisation with autologous oocytes (AO).MethodsA matched-pair analysis has been performed at the Centre for Reproductive Medicine of the UZ Brussel, Dutch speaking Free University of Brussel. A total of 410 pregnancies resulted in birth beyond 20 weeks of gestation occurring over a period of 10 years, including 205 oocyte donation pregnancies and 205 ICSI pregnancies with autologous oocytes (AO). Patients in the OD group were matched on a one-to-one basis with the AO group in terms of age, ethnicity, parity and plurality. Matched groups were compared using paired t-tests for continuous variables and McNemar test for categorical variables. A conditional logistic regression analyses was performed adjusting for paternal age, age of the oocyte donor, number of embryos transferred, and singleton/twin pregnancy.ResultsOocyte donation was associated with an increased risk of pregnancy induced hypertension (PIH) (matched OR: 1.502 CI: 1.024-2.204), and first trimester bleeding (matched OR: 1.493 CI: 1.036-2.15). No differences were observed between the two matched groups with regard to gestational age, mean birth weight and length, head circumference and Apgar scores.ConclusionsOocyte donation is associated with an increased risk for PIH and first trimester bleeding independent of the recipients’ age, parity and plurality, and independent of the age of the donor or the partner. However, oocyte donation has no impact on the overall perinatal outcome.

【 授权许可】

CC BY   
© Stoop et al.; licensee BioMed Central Ltd. 2012