Orthotopic liver transplantation in situs inversus adult from an ABO-incompatible donor with situs inversus

BMC Gastroenterology

Case Report

Sheng Yan¹  Min Zhang¹  Shusen Zheng¹  Songfeng Yu¹  Jian Wu¹  Hua Guo¹  Wu Zhang¹  Jun Yu¹ 

[1] Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, P.R. China;Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, 310003, Hangzhou, China;Key Laboratory of Organ Transplantation, Zhejiang Province, 310003, Hangzhou, China;

关键词: Liver transplantation;    Retransplantation;    Situs inversus;    Abo incompatible;   

DOI  :  10.1186/1471-230X-14-46

 received in 2013-08-10, accepted in 2014-02-24,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundSitus inversus is a rare congenital anomaly characterized by the complete inversion of thoracic and abdominal organs. Liver transplantation in such patients or from donors in situs inversus is technically challenging because of the reversed anatomic structures. A small number of successful liver transplantation cases concerning situs inverus in either recipients or donors have been recently reported with different graft position and orientation. Here we reported an extremely rare case of liver retransplantation from an ABO incompatible situs inversus donor to an adult situs inversus recipient.Case presentationA 53-year-old complete situs inversus man developed graft failure due to severe biliary complication after his first liver transplantation from a situs solitus donor. Re-transplantation was performed using a graft liver from a likewise situs inversus donor. Although the blood type between donor and recipient was incompatible, the post-operative outcome was excellent under proper prophylaxis to the antibody-mediated rejection.ConclusionTo the best of our knowledge, this is the first report of liver transplantation from situs inversus to situs inversus in adult recipient. Liver transplantation using situs matching donor makes the procedure much easier at the surgical point of view, which has a benefit of less potential surgical complications. Furthermore, ABO-incompatibility is acceptable for donor allocation in cases that both donor and recipient are situs inversus.

【 授权许可】

Unknown   
© Yu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.