History and phylogeny of intermediate filaments: Now in insects

BMC Biology

Commentary

Sergei V Strelkov¹  Harald Herrmann² 

[1] Faculteit Farmaceutische Wetenschappen Katholieke Universiteit Leuven Herestraat, 49 Bus 822, B-3000, Leuven, Belgium;Group Functional Architecture of the Cell (B065) German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany;

关键词: Lamin;    Intermediate Filament;    Coiled Coil;    Consensus Motif;    Intermediate Filament Protein;   

DOI  :  10.1186/1741-7007-9-16

 received in 2011-02-28, accepted in 2011-02-28,  发布年份 2011

来源: Springer

【 摘 要 】

Intermediate filaments include the nuclear lamins, which are universal in metazoans, and the cytoplasmic intermediate filaments, which are much more varied and form cell type-specific networks in animal cells. Until now, it has been thought that insects harbor lamins only. This view is fundamentally challenged by the discovery, reported in BMC Biology, of an intermediate filament-like cytoplasmic protein, isomin, in the hexapod Isotomurus maculatus. Here we briefly review the history of research on intermediate filaments, and discuss the implications of this latest finding in the context of what is known of their structure and functions.See research article: http://www.biomedcentral.com/1741-7007/9/17

【 授权许可】

CC BY   
© Herrmann; licensee BioMed Central Ltd. 2011