The epidemiology of bone cancer in 0 - 39 year olds in northern England, 1981 - 2002

BMC Cancer

Research Article

Rachel Eyre¹  Mark S Pearce¹  Emmanuel Mubwandarikwa¹  Richard JQ McNally¹  Karen Blakey¹  Peter W James¹  David Forman²  Patricia A McKinney³  Richard G Feltbower³ 

[1] Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, England, UK;Northern and Yorkshire Cancer Registry and Information Service, University of Leeds, LS9 7TF, Leeds, England, UK;Cancer Epidemiology Group, Leeds Institute of Genetics, Health & Therapeutics, Arthington House, Hospital Lane, LS16 6QB, LeedsEngland, UK;Cancer Information Section, International Agency for Research on Cancer, 150, cours Albert Thomas, F-69372, Lyon, Cedex 08, France;Paediatric Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, LS2 9JT, Leeds, England, UK;

关键词: Osteosarcoma;    Diagnostic Group;    Chondrosarcoma;    Ewing Sarcoma;    Bone Cancer;   

DOI  :  10.1186/1471-2407-10-357

 received in 2009-11-19, accepted in 2010-07-06,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThere is a paucity of recent epidemiological data on bone cancers. The aim of this study was to describe incidence and survival patterns for bone cancers diagnosed during 1981 - 2002.MethodsCases aged 0 - 39 years (236 osteosarcomas, 166 Ewing sarcomas and 73 chondrosarcomas) were analysed using Poisson and Cox regressions.ResultsIncidence rates (per million persons per year) for osteosarcoma were 2.5 at age 0 - 14 years; 4.5 at age 15 - 29 years and 1.0 at age 30 - 39 years. Similarly, for Ewing sarcoma the incidence rates were 2.2; 2.9; 0.4 and for chondrosarcoma rates were 0.1; 1.2; 1.8 respectively. Incidence of osteosarcoma increased at an average annual rate of 2.5% (95% CI 0.4 - 4.7; P = 0.02), but there was no change in incidence of Ewing sarcoma or chondrosarcoma. There was a marginally statistically significant improvement in survival for Ewing sarcoma (hazard ratio (HR) per annum = 0.97; 95% CI 0.94 - 1.00; P = 0.06), although patients aged 15 - 39 years (n = 93) had worse overall survival than those aged 0 - 14 (n = 73; HR = 1.46; 95% CI 0.98 - 2.17; P = 0.06). There was no significant improvement in osteosarcoma survival (HR per annum = 0.98; 95% CI 0.95 - 1.01; P = 0.18).ConclusionsReasons for poorer survival in Ewing sarcoma patients aged 15 - 39 years and failure to significantly improve survival for osteosarcoma patients requires further investigation.

【 授权许可】

Unknown   
© Eyre et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.