Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition

Nutrition Journal

Research

S. Shepherd¹  A. S. Traoré²  C. W. Yaméogo³  K. D. Stark⁴  C. Fabiansen⁵  M. J. H. Rytter⁵  B. Cichon⁵  K. F. Michaelsen⁵  H. Friis⁵  L. Lauritzen⁵  D. Faurholt-Jepsen⁶  V. B. Christensen⁷  A. Briend⁸ 

[1] Alliance for International Medical Action, Dakar, Sénégal;Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles, Université Ouaga I Prof Joseph KI-ZERBO, Ouagadougou, Burkina Faso;Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles, Université Ouaga I Prof Joseph KI-ZERBO, Ouagadougou, Burkina Faso;Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark;Département Biomédical et Santé Publique, Institut de Recherche en Sciences de la Santé, 03 BP 7192, Ouagadougou 03, Burkina Faso;Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada;Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark;Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark;Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark;Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark;Médecins Sans Frontières — Denmark, Copenhagen, Denmark;Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark;Tampere Centre for Child Health Research, 33014 University of Tampere, Tampere, Finland;

关键词: Essential fatty acids;    Undernourished children;    Diet;    Morbidity;   

DOI  :  10.1186/s12937-017-0264-3

 received in 2017-01-10, accepted in 2017-06-25,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSevere acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.MethodsWe conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6–23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.ResultsChildren with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.ConclusionWhile PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.Trial registrationThe trial is registered at http://www.isrctn.com (ISRCTN42569496).

【 授权许可】

CC BY   
© The Author(s). 2017